Evidence map›Paper›PMID 28328553›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2017

Determinants of HIV Phylogenetic Clustering in Chicago Among Young Black Men Who Have Sex With Men From the uConnect Cohort.

Ethan Morgan, Amesika N Nyaku, Richard T DʼAquila, John A Schneider

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ethan Morgan*Department of Public Health Sciences, University of Chicago, Chicago, IL; †Department of Medicine, Northwestern University, Chicago, IL; and ‡Department of Medicine, University of Chicago, Chicago, IL.
Amesika N Nyaku
Richard T DʼAquila
John A Schneider
Chicago Department of Public Health · USNorthwestern University · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Grace C. John-Stewart · 1988 to 2026
$104.9M
Virology and Immunology Technology CoreP30AI117943 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Sahera Dirajlal-Fargo · 2015 to 2026
$38.4M
HIV intervention models for criminal justice involved substance-using Black MSMR01DA039934 · NIDA · UNIVERSITY OF CHICAGO · PI FUJIMOTO, KAYO, HARAWA, NINA THAWATA · 2015 to 2019
$3.6M
Social Network Dynamics, HIV, and Risk Reduction Among Younger Black MSMR01DA033875 · NIDA · NATIONAL OPINION RESEARCH CENTER · PI SCHNEIDER, JOHN · 2012 to 2016
$3.0M
Digital communication networks in men at risk for HIVR21MH098768 · NIMH · UNIVERSITY OF CHICAGO · PI SCHNEIDER, JOHN · 2012 to 2013
$445k
NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI117943NIAID NIH HHS UM1 AI068636NIDA NIH HHS R01 DA033875NIDA NIH HHS R01 DA039934NIMH NIH HHS R21 MH098768
6 · The paper itself

Abstract

introductionPhylogenetic analysis determines similarities among HIV genetic sequences from persons infected with HIV, identifying clusters of transmission. We determined characteristics associated with both membership in an HIV transmission cluster and the number of clustered sequences among a cohort of young black men who have sex with men (YBMSM) in Chicago.

methodsPairwise genetic distances of HIV-1 pol sequences were collected during 2013-2016. Potential transmission ties were identified among HIV-infected persons whose sequences were ≤1.5% genetically distant. Putative transmission pairs were defined as ≥1 tie to another sequence. We then determined demographic and risk attributes associated with both membership in an HIV transmission cluster and the number of ties to the sequences from other persons in the cluster.

resultsOf 86 available sequences, 31 (36.0%) were tied to ≥1 other sequence. Through multivariable analyses, we determined that those who reported symptoms of depression and those who had a higher number of confidants in their network had significantly decreased odds of membership in transmission clusters. We found that those who had unstable housing and who reported heavy marijuana use had significantly more ties to other individuals within transmission clusters, whereas those identifying as bisexual, those participating in group sex, and those with higher numbers of sexual partners had significantly fewer ties.

conclusionsThis study demonstrates the potential for combining phylogenetic and individual and network attributes to target HIV control efforts to persons with potentially higher transmission risk, as well as suggesting some unappreciated specific predictors of transmission risk among YBMSM in Chicago for future study.

Indexed as

AdolescentAdultBlack or African AmericanChicagoCluster AnalysisHIVHIV InfectionsHomosexuality, MaleHumansLongitudinal StudiesMalePhylogenyRisk FactorsSocial SupportYoung Adult

Identifiers

PMID28328553
PMCPMC5472497
OpenAlexW2599617005

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.