ArticleNeurosurgery2017
Factors Associated With Pre- and Postoperative Seizures in 1033 Patients Undergoing Supratentorial Meningioma Resection.
Article in Neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Oedema as a prognostic factor for seizures in meningioma - a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Predictors of early and late postoperative seizures in meningioma patients: a systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Peritumoral T2/FLAIR hyperintense MRI findings of meningiomas are not necessarily edema and may persist permanently: a systematic review.Neurosurgical review · 2023Pooled it
- Sporadic Multiple Meningiomas Presenting With Drug-Resistant Seizures in a Young Adult: A Case Report.Cureus · 2026Article
- Probabilistic MRI Maps for the Presentation and Management of Intracranial Meningiomas.Radiology. Imaging cancer · 2026Article
- Glioma region-specific metabolites associated with patient seizures.Journal of neuro-oncology · 2026Article
- FOXC1 as a molecular predictor of postoperative peritumoral edema resolution in meningiomas.Journal of neuro-oncology · 2026Article
- FOXC1 expression and radiological predictors of peritumoral brain edema in meningiomas.Journal of neuro-oncology · 2026Article
- MRI radiomic signature predicts peritumoral brain edema resolution following meningioma surgery.Acta neurochirurgica · 2025Article
- Review
- Article
- Antiseizure medications for preventing a first seizure in adults with a brain tumour.The Cochrane database of systematic reviews · 2025Article
- Peritumoral edema resolves infrequently in surgically treated patients with intracranial meningioma- a retrospective study of 279 meningioma patients.Journal of neuro-oncology · 2025Article
- Meningiomas-Related Epilepsy After Surgery.Cancers · 2025Article
- Predictors of Postoperative Epilepsy/Seizures in Patients Readmitted After Meningioma Resection.Behavioural neurology · 2025Article
- Article
- Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients.Neuro-oncology · 2024Review
- Predictors for the Occurrence of Seizures in Meningioma.Cancers · 2024Article
- The Impact of Molecular and Genetic Analysis on the Treatment of Patients with Atypical Meningiomas.Diagnostics (Basel, Switzerland) · 2024Review
- Perifocal edema is a risk factor for preoperative seizures in patients with meningioma WHO grade 2 and 3.Acta neurochirurgica · 2024Article
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7 authors.
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Abstract
backgroundRisk factors for pre- and postoperative seizures in supratentorial meningiomas are understudied compared to other brain tumors.
objectiveTo report seizure frequency and identify factors associated with pre- and postoperative seizures in a large single-center population study of patients undergoing resection of supratentorial meningioma.
methodsRetrospective chart review of 1033 subjects undergoing resection of supratentorial meningioma at the author's institution (1991-2014). Multivariate regression was used to identify variables significantly associated with pre- and postoperative seizures.
resultsPreoperative seizures occurred in 234 (22.7%) subjects. At 5 years postoperative, probability of seizure freedom was 89.9% among subjects without preoperative seizures and 62.2% with preoperative seizures. Multivariate analysis identified the following predictors of preoperative seizures: presence of ≥1 cm peritumoral edema (odds ratio [OR]: 4.45, 2.55-8.50), nonskull base tumor location (OR: 2.13, 1.26-3.67), greater age (OR per unit increase: 1.03, 1.01-1.05), while presenting symptom of headache (OR: 0.50, 0.29-0.84) or cranial nerve deficit (OR: 0.36, 0.17-0.71) decreased odds of preoperative seizures. Postoperative seizures after discharge were associated with preoperative seizures (OR: 5.70, 2.57-13.13), in-hospital seizure (OR: 4.31, 1.28-13.67), and among patients without preoperative seizure, occurrence of medical or surgical complications (OR 3.39, 1.09-9.48). Perioperative anti-epileptic drug use was not associated with decreased incidence of postoperative seizures.
conclusionsNonskull base supratentorial meningiomas with surrounding edema have the highest risk for preoperative seizure. Long-term follow-up showing persistent seizures in meningioma patients with preoperative seizures raises the possibility that these patients may benefit from electrocorticographic mapping of adjacent cortex and resection of noneloquent, epileptically active cortex.
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