ArticleScientific reports2017
Adiposity in childhood brain tumors: A report from the Canadian Study of Determinants of Endometabolic Health in Children (CanDECIDE Study).
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Implications of adipocyte dysfunction in pediatric obesity: a narrative review.Pediatric endocrinology, diabetes, and metabolism · 2026Review
- Review
- Metabolic Implications of Childhood Cancer.Current pediatrics reports · 2025Article
- Bioelectrical Impedance Analysis of Body Composition in Male Childhood Brain Tumor Survivors.Diseases (Basel, Switzerland) · 2024Article
- Prevalence of osteopathologies in a single center cohort of survivors of childhood primary brain tumor.Frontiers in pediatrics · 2022Article
- High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors.Scientific reports · 2020Article
- Circulating leptin levels are associated with adiposity in survivors of childhood brain tumors.Scientific reports · 2020Article
- Tri-ponderal mass index in survivors of childhood brain tumors: A cross-sectional study.Scientific reports · 2018Article
- Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study.Scientific reports · 2018Article
- Understanding muscle-immune interactions in adolescent idiopathic scoliosis: a feasibility study.Pilot and feasibility studies · 2017Article
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
Children with brain tumors (CBT) are at high risk of cardiovascular diseases and type 2 diabetes compared to the general population. Recently, adiposity has been reported to be more informative for cardiometabolic risk stratification than body mass index (BMI) in the general population. The goal of this study is to describe the adiposity phenotype in CBT, and to establish adiposity determinants. We recruited CBT (n = 56) and non-cancer controls (n = 106). Percent body fat (%FM), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were measured to determine total and central adiposity, respectively. Regression analyses were used to evaluate adiposity determinants. CBT had higher total and central adiposity compared to non-cancer controls despite having similar BMI measurements. Those with tumors at the supratentorial region had increased total and central adiposity, while those who received radiotherapy had increased total adiposity. In conclusion, CBT have increased total and central adiposity in the presence of similar BMI levels when compared to non-cancer controls. Adiposity, especially central adiposity, is a potential cardiometabolic risk factor present relatively early in life in CBT. Defining interventions to target adiposity may improve long-term outcomes by preventing cardiometabolic disorders in CBT.
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Registered trials
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