Evidence map›Paper›PMID 28327605›Full record

ArticleScientific reports2017

Ginsenoside Rb1 protects against ischemia/reperfusion-induced myocardial injury via energy metabolism regulation mediated by RhoA signaling pathway.

Yuan-Chen Cui, Chun-Shui Pan, Li Yan, Lin Li, Bai-He Hu, Xin Chang, Yu-Ying Liu, Jing-Yu Fan, Kai Sun, Quan -Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yuan-Chen CuiDepartment of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Chun-Shui PanTasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China.
Li YanTasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China.
Lin LiDepartment of Cardiology, Beijing China-Japan Friendship Hospital, Beijing 100029, China.
Bai-He HuTasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China.
Xin ChangTasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China.
Yu-Ying LiuTasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China.
Jing-Yu FanTasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China.
Kai SunTasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China.
Quan -LiTasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China.
Jing-Yan HanDepartment of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Beijing Royal Integrative Medicine Hospital · CNPeking University · CNChina-Japan Friendship Hospital · CNState Administration of Traditional Chinese Medicine of the People's Republic of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac ischemia and reperfusion (I/R) injury remains a challenge for clinicians. Ginsenoside Rb1 (Rb1) has been reported to have the ability to attenuate I/R injury, but its effect on energy metabolism during cardiac I/R and the underlying mechanism remain unknown. In this study, we detected the effect of Rb1 on rat myocardial blood flow, myocardial infarct size, cardiac function, velocity of venule red blood cell, myocardial structure and apoptosis, energy metabolism and change in RhoA signaling pathway during cardiac I/R injury. In addition, the binding affinity of RhoA to Rb1 was detected using surface plasmon resonance (SPR). Results showed that Rb1 treatment at 5 mg/kg/h protected all the cardiac injuries induced by I/R, including damaged myocardial structure, decrease in myocardial blood flow, impaired heart function and microcirculation, cardiomyocyte apoptosis, myocardial infarction and release of myocardial cTnI. Rb1 also inhibited the activation of RhoA signaling pathway and restored the production of ATP during cardiac I/R. Moreover, SPR assay showed that Rb1 was able to bind to RhoA in a dose-dependent manner. These results indicate that Rb1 may prevent I/R-induced cardiac injury by regulation of RhoA signaling pathway, and may serve as a potential regime to improve percutaneous coronary intervention outcome.

Indexed as

Adenosine TriphosphateAnimalsApoptosisBlood Flow VelocityCardiotonic AgentsEnergy MetabolismGene Expression RegulationGinsenosidesHeart Function TestsMaleMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacProtein BindingRatsAdenosine TriphosphateCardiotonic Agentsginsenoside Rb1GinsenosidesRhoA protein, ratrho GTP-Binding ProteinsTroponin I

Identifiers

PMID28327605
PMCPMC5361119
OpenAlexW2601984476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.