ArticlePsychiatry research2017
Prenatal tobacco exposure, birthweight, and offspring psychopathology.
Article in Psychiatry research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Impact of Maternal Smoking During Pregnancy on Depressive and Anxiety Behaviors in Offspring: A Meta-analysis.Depression and anxiety · 2025Pooled it
- Prenatal smoking, alcohol and caffeine exposure and offspring externalizing disorders: a systematic review and meta-analysis.Addiction (Abingdon, England) · 2022Pooled it
- Prenatal tobacco use and the risk of mood disorders in offspring: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2020Pooled it
- Stage-specific effects of early-life tobacco exposure on mental health, inflammation, and brain structure-function coupling.Translational psychiatry · 2026Article
- The Consequences of Prenatal Tobacco Exposure: A Systematic Review of Birth Outcomes and Developmental Trajectories.Cureus · 2026Review
- The Impact of Maternal/In Utero Exposure of Novel Tobacco Products on the Offspring Cardiovascular Health.Cardiovascular toxicology · 2025Review
- Longitudinal mapping of cortical change during early adolescence associated with prenatal tobacco and/or alcohol exposure in the Adolescent Brain Cognitive Development Study.bioRxiv : the preprint server for biology · 2024Article
- Association of adverse prenatal exposure burden with child psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study.PloS one · 2021Article
- Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome.Molecular psychiatry · 2020Article
- A Scoping Review of Non-Occupational Exposures to Environmental Pollutants and Adult Depression, Anxiety, and Suicide.Current environmental health reports · 2020Article
- Effects of parental smoking and indoor tobacco smoke exposure on respiratory outcomes in children.Scientific reports · 2020Article
- Nicotine exposure during pregnancy programs osteopenia in male offspring ratsFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Gestational exposure to nicotine and/or benzo[a]pyrene causes long-lasting neurobehavioral consequences.Birth defects research · 2019Article
- Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women.International journal of environmental research and public health · 2018Article
- Adults' Perceptions of Nicotine Harm to Children.Pediatrics · 2018Article
- Prevalence and risk factors of psychiatric disorders in early adolescence: 2004 Pelotas (Brazil) birth cohort.Social psychiatry and psychiatric epidemiology · 2018Article
- Impact of prenatal exposure characterization on early risk detection: Methodologic insights for the HEALthy Brain and Child Development (HBCD) study.Neurotoxicology and teratologyArticle
- Dimension- and context-specific expression of preschoolers' disruptive behaviors associated with prenatal tobacco exposure.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Although prenatal tobacco exposure (PTE) is associated with several adverse offspring mental health outcomes, mechanisms remain unclear. We test whether associations between PTE and offspring psychopathology are explained by birthweight, one of the earliest-occurring outcomes of PTE. The analysis focuses on 238 offspring from a family study of depression with (1) collected prenatal histories and (2) at least one clinical interview in adulthood to assess psychiatric problems. Exposure was categorized by maternal smoking of ≥10 cigarettes daily/nearly daily; diagnostic outcomes were confirmed by clinicians using the best-estimate procedure, blind to exposure. After adjusting for potential confounders, PTE was associated with 0.7lb(9%) lower birthweight (p=0.0002), increased rates of disruptive behavior disorders [males: OR=2.66(1.15,6.16), and (trend) substance use disorders [females: OR=2.23(0.98,5.09)], and decreased rates of mood disorders (males: OR=0.42(0.17,0.98)]. Birthweight was not independently associated with diagnoses and did not mediate the association between exposure and psychopathology. Maternal smoking has long-term adverse consequences for offspring. Although birthweight cannot be manipulated, smoking is a modifiable risk factor. Thus, cessation efforts focused on pregnant women may not only improve maternal wellbeing, but also mitigate adverse proximal (e.g., birthweight) and long-term (psychopathology) outcomes in offspring.
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