ReviewNeuroscience and biobehavioral reviews2017
Acoustic startle modification as a tool for evaluating auditory function of the mouse: Progress, pitfalls, and potential.
Review in Neuroscience and biobehavioral reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Differences in hearing across the lifespan in two strains of Alzheimer's mouse models as measured using behavioral and physiological techniques.Hearing research · 2026Article
- Loss of Thy1 in Cortico-Striatal Pathways Alters Response to Dopamine and Gabapentin.ASN neuro · 2026Article
- Sound-seeking before and after hearing loss in mice.Scientific reports · 2024Article
- Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise.The Journal of the Acoustical Society of America · 2024Article
- Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities in mice.Current biology : CB · 2024Article
- Sound-seeking before and after hearing loss in mice.bioRxiv : the preprint server for biology · 2024Article
- Universal automated classification of the acoustic startle reflex using machine learning.Hearing research · 2023Article
- TheFrontiers in behavioral neuroscience · 2023Article
- Exposure to Circadian Disruption During Adolescence Interacts With a Genetic Risk Factor to Modify Schizophrenia-relevant Behaviors in a Sex-dependent Manner.Journal of biological rhythms · 2022Article
- Auditory Behavior in Adult-Blinded Mice.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Roadbumps at the Crossroads of Integrating Behavioral andFrontiers in toxicology · 2022Review
- A genetically identified population of layer 4 neurons in auditory cortex that contributes to pre-pulse inhibition of the acoustic startle response.Frontiers in neural circuits · 2022Article
- Prepulse inhibition predicts subjective hearing in rats.Scientific reports · 2021Article
- Robust and replicable measurement for prepulse inhibition of the acoustic startle response.Molecular psychiatry · 2021Article
- Hyperexcitability and Homeostasis in Fragile X Syndrome.Frontiers in molecular neuroscience · 2021Article
- Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus.Neural plasticity · 2021Article
- GABAFrontiers in integrative neuroscience · 2021Article
- Automated classification of acoustic startle reflex waveforms in young CBA/CaJ mice using machine learning.Journal of neuroscience methods · 2020Article
- Fetal gene therapy and pharmacotherapy to treat congenital hearing loss and vestibular dysfunction.Hearing research · 2020Review
- A Cortico-Collicular Amplification Mechanism for Gap Detection.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Acoustic startle response (ASR) modification procedures, especially prepulse inhibition (PPI), are increasingly used as behavioral measures of auditory processing and sensorimotor gating in rodents due to their perceived ease of implementation and short testing times. In practice, ASR and PPI procedures are extremely variable across animals, experimental setups, and studies, and the interpretation of results is subject to numerous caveats and confounding influences. We review considerations for modification of the ASR using acoustic stimuli, and we compare the sensitivity of PPI procedures to more traditional operant psychoacoustic techniques. We also discuss non-auditory variables that must be considered. We conclude that ASR and PPI measures cannot substitute for traditional operant techniques due to their low sensitivity. Additionally, a substantial amount of pilot testing must be performed to properly optimize an ASR modification experiment, negating any time benefit over operant conditioning. Nevertheless, there are some circumstances where ASR measures may be the only option for assessing auditory behavior, such as when testing mouse strains with early-onset hearing loss or learning impairments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.