Evidence map›Paper›PMID 28327356›Full record

ArticleBiochemical and biophysical research communications2017

Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP.

Emma Kruglov, Meenakshisundaram Ananthanarayanan, Pedro Sousa, Jittima Weerachayaphorn, Mateus T Guerra, Michael H Nathanson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Emma KruglovDigestive Diseases Section, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8019, USA.
Meenakshisundaram AnanthanarayananDigestive Diseases Section, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8019, USA.
Pedro SousaDigestive Diseases Section, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8019, USA.
Jittima WeerachayaphornDigestive Diseases Section, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8019, USA.
Mateus T GuerraDigestive Diseases Section, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8019, USA.
Michael H NathansonDigestive Diseases Section, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8019, USA. Electronic address: michael.nathanson@yale.edu.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Translational CoreP01DK057751 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2001 to 2020
$25.6M
CALCIUM WAVES IN HEPATOCYTES--MECHANISMS AND EFFECTSR01DK045710 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 1999 to 2014
$5.7M
Regulation of cholestasis by inositol trisphosphate receptorsR56DK099470 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2015 to 2015
$246k
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS P01 DK057751NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R01 DK045710NIDDK NIH HHS R56 DK099470
6 · The paper itself

Abstract

The type 2 inositol 1,4,5-trisphosphate receptor (IP3R2) is the principal intracellular Ca

Indexed as

Response ElementsAdenylyl CyclasesAnimalsBinding SitesColforsinCREB-Binding ProteinCyclic AMPDactinomycinFastingGene Expression RegulationHepatocytesHep G2 CellsHumansInositol 1,4,5-Trisphosphate ReceptorsMaleMutation8-((4-chlorophenyl)thio)cyclic-3',5'-AMPadenylate cyclase 9adenylyl cyclase 6Adenylyl CyclasesColforsinCREB-Binding ProteinCrebbp protein, ratCyclic AMPDactinomycinInositol 1,4,5-Trisphosphate ReceptorsRNA, MessengerThionucleotidesBile secretionCalcium signalingCyclic AMPHepatocytesType 2 inositol 1,4,5-trisphosphate receptor

Identifiers

PMID28327356
PMCPMC5421629
OpenAlexW2599688686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.