Evidence map›Paper›PMID 28327272›Full record

ArticleCanadian journal of surgery. Journal canadien de chirurgie2017

Effects of electrospun scaffolds of di-

Jacek Drobnik, Izabella Krucinska, Agnieszka Komisarczyk, Stanislaw Sporny, Alicja Szczepanowska, Joanna Ciosek

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of surgery. Journal canadien de chirurgie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jacek DrobnikFrom the Laboratory of Connective Tissue Metabolism, Medical University of Lodz, Lodz, Poland (Drobnik, Szczepanowska); the Department of Material and Commodity Sciences and Textile Metrology, Lodz University of Technology, Lodz, Poland (Krucinska, Komisarczyk); the Department of Dental Pathology, Medical University of Lodz, Lodz, Poland (Sporny); and the Department of Neuropeptides Research, Medical University of Lodz, Lodz, Poland (Ciosek); .
Izabella KrucinskaFrom the Laboratory of Connective Tissue Metabolism, Medical University of Lodz, Lodz, Poland (Drobnik, Szczepanowska); the Department of Material and Commodity Sciences and Textile Metrology, Lodz University of Technology, Lodz, Poland (Krucinska, Komisarczyk); the Department of Dental Pathology, Medical University of Lodz, Lodz, Poland (Sporny); and the Department of Neuropeptides Research, Medical University of Lodz, Lodz, Poland (Ciosek); .
Agnieszka KomisarczykFrom the Laboratory of Connective Tissue Metabolism, Medical University of Lodz, Lodz, Poland (Drobnik, Szczepanowska); the Department of Material and Commodity Sciences and Textile Metrology, Lodz University of Technology, Lodz, Poland (Krucinska, Komisarczyk); the Department of Dental Pathology, Medical University of Lodz, Lodz, Poland (Sporny); and the Department of Neuropeptides Research, Medical University of Lodz, Lodz, Poland (Ciosek); .
Stanislaw SpornyFrom the Laboratory of Connective Tissue Metabolism, Medical University of Lodz, Lodz, Poland (Drobnik, Szczepanowska); the Department of Material and Commodity Sciences and Textile Metrology, Lodz University of Technology, Lodz, Poland (Krucinska, Komisarczyk); the Department of Dental Pathology, Medical University of Lodz, Lodz, Poland (Sporny); and the Department of Neuropeptides Research, Medical University of Lodz, Lodz, Poland (Ciosek); .
Alicja SzczepanowskaFrom the Laboratory of Connective Tissue Metabolism, Medical University of Lodz, Lodz, Poland (Drobnik, Szczepanowska); the Department of Material and Commodity Sciences and Textile Metrology, Lodz University of Technology, Lodz, Poland (Krucinska, Komisarczyk); the Department of Dental Pathology, Medical University of Lodz, Lodz, Poland (Sporny); and the Department of Neuropeptides Research, Medical University of Lodz, Lodz, Poland (Ciosek); .
Joanna CiosekFrom the Laboratory of Connective Tissue Metabolism, Medical University of Lodz, Lodz, Poland (Drobnik, Szczepanowska); the Department of Material and Commodity Sciences and Textile Metrology, Lodz University of Technology, Lodz, Poland (Krucinska, Komisarczyk); the Department of Dental Pathology, Medical University of Lodz, Lodz, Poland (Sporny); and the Department of Neuropeptides Research, Medical University of Lodz, Lodz, Poland (Ciosek); .
Lodz University of Technology · PLMedical University of Lodz · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe sought to determine the usefulness of electrospun dibutyrylchitin (DBC) or poly-(ε-caprolactone [PCL]), in wound treatment. We investigated the mechanisms of action of these polymers on wound healing.

methodsWe synthesized DBC, a newly identified ester derivative of chitin, using a patented method comprising the substitution of butyryl groups at positions C-3 and C-6 in chitin molecules. We confirmed the double substitution by the butyric groups using infrared spectrometry. The fibrous scaffolds were obtained using the electrospinning method. A polypropylene net was implanted subcutaneously in the rat and served as a wound model.

resultsBoth DBC and PCL increased granulation tissue weight in the wound. In contrast to PCL, DBC did not abolish glycosaminoglycan changes in wounds. The tested samples did not impair total collagen synthesis or induce excessive fibrosis. In both PCL- and DBC-treated wounds, we observed a lower level of soluble collagen (compared with controls). The results show better hydration of the wounds in both the DBC and PCL groups. No induction of large edema formation by the tested materials was observed. These polymers induced almost identical macrophage-mediated reactions to foreign-body implantation. The implants increased the blood vessel number in a wound.

conclusionBoth PCL and DBC could be used as scaffolds or dressings for wound treatment. The materials were safe and well tolerated by animals. As DBC did not disturb glycosaminoglycan accumulation in wounds and absorbed twice as much liquid as PCL, it can be considered superior.

Indexed as

Tissue ScaffoldsWound HealingAnimalsCaproatesChitinLactonesMaleRatsRats, WistarWounds and InjuriesCaproatescaprolactoneChitindi-O-butyrylchitinLactones

Identifiers

PMID28327272
PMCPMC5453758
OpenAlexW2621004867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.