Evidence map›Paper›PMID 28327161›Full record

Trial reportJournal of neuroengineering and rehabilitation2017

Rehabilitation of hand function after spinal cord injury using a novel handgrip device: a pilot study.

Haydn Hoffman, Tiffany Sierro, Tianyi Niu, Melanie E Sarino, Majid Sarrafzadeh, David McArthur, V Reggie Edgerton, Daniel C Lu

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neuroengineering and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
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  4. In Memoriam: V. Reggie Edgerton.Journal of neuroengineering and rehabilitation · 2026
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Haydn HoffmanDepartment of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Ste. 536, Los Angeles, CA, 90095-6901, USA.
Tiffany SierroDepartment of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Ste. 536, Los Angeles, CA, 90095-6901, USA.
Tianyi NiuDepartment of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Ste. 536, Los Angeles, CA, 90095-6901, USA.
Melanie E SarinoRancho Los Amigos National Rehabilitation Center, Downey, CA, 90242, USA.
Majid SarrafzadehWireless Health Institute, University of California Los Angeles, Los Angeles, CA, USA.
David McArthurDepartment of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Ste. 536, Los Angeles, CA, 90095-6901, USA.
V Reggie EdgertonDepartment of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Ste. 536, Los Angeles, CA, 90095-6901, USA.
Daniel C LuDepartment of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Ste. 536, Los Angeles, CA, 90095-6901, USA. dclu@mednet.ucla.edu.
University of California, Los Angeles · USRancho Los Amigos National Rehabilitation Center · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Enabling forelimb function with agonist drug and epidural stimulation in SCIU01EB015521 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE, LU, DANIEL · 2013 to 2017
$6.0M
Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCIR01EB007615 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE · 2008 to 2013
$4.9M
NCATS NIH HHS UL1 TR000124NIBIB NIH HHS R01 EB007615NIBIB NIH HHS U01 EB015521
6 · The paper itself

Abstract

backgroundActivity-based therapy (ABT) for patients with spinal cord injury (SCI), which consists of repetitive use of muscles above and below the spinal lesion, improves locomotion and arm strength. Less data has been published regarding its effects on hand function. We sought to evaluate the effects of a weekly hand-focused therapy program using a novel handgrip device on grip strength and hand function in a SCI cohort.

methodsPatients with SCI were enrolled in a weekly program that involved activities with the MediSens (Los Angeles, CA) handgrip. These included maximum voluntary contraction (MVC) and a tracking task that required each subject to adjust his/her grip strength according to a pattern displayed on a computer screen. For the latter, performance was measured as mean absolute accuracy (MAA). The Spinal Cord Independence Measure (SCIM) was used to measure each subject's independence prior to and after therapy.

resultsSeventeen patients completed the program with average participation duration of 21.3 weeks. The cohort included patients with American Spinal Injury Association (ASIA) Impairment Scale (AIS) A (n = 12), AIS B (n = 1), AIS C (n = 2), and AIS D (n = 2) injuries. The average MVC for the cohort increased from 4.1 N to 21.2 N over 20 weeks, but did not reach statistical significance. The average MAA for the cohort increased from 9.01 to 21.7% at the end of the study (p = .02). The cohort's average SCIM at the end of the study was unchanged compared to baseline.

conclusionsA weekly handgrip-based ABT program is feasible and efficacious at increasing hand task performance in subjects with SCI.

Indexed as

Self-Help DevicesAdultFemaleHand StrengthHumansMaleMiddle AgedNeurological RehabilitationPilot ProjectsSpinal Cord InjuriesActivity-based therapyHand functionNeurorehabilitationSpinal cord injury

Identifiers

PMID28327161
PMCPMC5361778
OpenAlexW2600260805

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.