ArticleBMC oral health2017
The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints.
Article in BMC oral health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02418520 (The Effect of Miswak Chewing Sticks on the Oral Helicobacter Pylori Infection), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Miswak Chewing Sticks on the Oral Helicobacter Pylori Infection
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Possible Association of Periodontal Diseases WithFrontiers in medicine · 2022Pooled it
- Halitosis andJGH open : an open access journal of gastroenterology and hepatology · 2026Review
- Article
- Review
- Poor Oral Hygiene: A Hidden Risk Factor for Helicobacter pylori Infection.International dental journal · 2025Article
- Clinical Evaluation and Microbiological Identification of Helicobacter Pylori in Patients with Oral Ulcerations Using the Polymerase Chain Reaction (PCR) Method.Materia socio-medica · 2025Article
- Oral pathogens meet the gut microbiome: new mechanistic insights on systemic disease.Frontiers in cellular and infection microbiology · 2025Review
- Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment-The Role of Ceragenins in the Development of New Therapeutic Methods.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Helicobacter pylori in oral cavity: current knowledge.Clinical and experimental medicine · 2024Review
- The role of periodontitis in cancer development, with a focus on oral cancers.Molecular biology reports · 2024Review
- Association between the presence and genotype ofExperimental and therapeutic medicine · 2023Article
- Review
- Review
- Comparing the prevalence of Helicobacter pylori and virulence factors cagA, vacA, and dupA in supra-gingival dental plaques of children with and without dental caries: a case-control study.BMC oral health · 2022Article
- DNA diagnostics for reliable and universal identification ofWorld journal of gastroenterology · 2021Review
- Overview ofDiseases (Basel, Switzerland) · 2021Review
- What Is New inJournal of clinical medicine · 2021Review
- Differential Signature of the Microbiome and Neutrophils in the Oral Cavity of HIV-Infected Individuals.Frontiers in immunology · 2021Article
- Can children's oral hygiene and sleep routines be compromised during the COVID-19 pandemic?International journal of paediatric dentistry · 2021Article
- Effects of eradication of Helicobacter pylori on oral malodor and the oral environment: a single-center observational study.BMC research notes · 2020Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe oral cavity can be an extra-gastric reservoir for Helicobacter pylori (H.pylori). This can play a role in the pathogenesis of halitosis, glossitis, recurrent aphthous stomatitis, and dental caries. The present study was conducted to detect the presence of H.pylori within the dental biofilm and in saliva samples collected from children suffering from dyspepsia and children without any gastrointestinal complaints. Associations with gastric infection, halitosis, and some oral parameters were also evaluated.
methodsSeventy children (aged between 5-16) with dyspepsia were selected for the study group and control group composed of 30 healthy children without dyspepsia were also included in the study. After detailed oral and clinical examinations for oral parameters, saliva, and supragingival dental biofilm samples were collected for 16S rRNA and 23S rRNA genes detection by real-time polymerase chain reaction (RT-PCR). The presence of gastric H.pylori was evaluated in endoscopic biopsy specimens histopathologically. Halitosis was evaluated by benzoyl-DL-arginine-naphthylamid (BANA) test. Salivary S.mutans and Lactobacilli sp. counts were also carried out by commercial kits.
resultsH.pylori was histopathologically detected amongst 83% of the children with the dyspeptic condition. The detection rate of this bacteria in dental biofilm and saliva samples and halitosis were found relatively higher in the dyspeptic children rather than the control group (p < 0.01). Halitosis was not significantly different between dyspeptic children and those detected with H.pylori (p > 0.05). In the gastric H.pylori positive group with dyspepsia, DMFT/S and dmft/s numbers and plaque indices were found higher than the control group (p < 0.01). Only plaque indices of gastric H.pylori negative group with dyspepsia were found higher than the control group (p < 0.01). S.mutans and Lactobacilli sp. counts were not significantly different between gastric H.pylori positive and negative groups (p > 0.05). Comparing to those with negative for both genes, in children whose dental biofilm and saliva samples were positive for both 16S rRNA and 23S rRNA genes, significantly higher results for halitosis, and DMFS numbers and significantly lower results for dmfs numbers and pH values were found (p < 0.01).
conclusionsHelicobacter pylori can occur in the oral cavity aside and independently from the stomach. However, the high number of bacteria in the oral cavities of children with gastric H.pylori, an association between the presence of H.pylori and halitosis, DMFS, and pH were found.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.