ArticleBMC psychiatry2017
Brain structure differences among male schizophrenic patients with history of serious violent acts: an MRI voxel-based morphometric study.
Article in BMC psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 2 of them syntheses that pooled it.
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17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis.Frontiers in human neuroscience · 2023Pooled it
- Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation.Frontiers in psychiatry · 2022Pooled it
- Individual-level deviations from normative brain morphology in violence, psychosis, and psychopathy.Translational psychiatry · 2025Article
- Corticolimbic Structural Deficits in Violent Patients with Schizophrenia.Brain sciences · 2025Article
- The relationship between cognitive function and cortical thickness in first-episode drug-naive schizophrenia patients with agitation.Frontiers in psychiatry · 2025Article
- Brain structural alterations associated with impulsiveness in male violent patients with schizophrenia.BMC psychiatry · 2024Article
- Meta-analysis of structural and functional brain abnormalities in early-onset schizophrenia.Frontiers in psychiatry · 2024Article
- Neuroanatomical correlates of aggressiveness: a case-control voxel- and surface-based morphometric study.Brain structure & function · 2024Article
- Prediction of violence in male schizophrenia using sMRI, based on machine learning algorithms.BMC psychiatry · 2022Article
- Structural Deficits in the Frontotemporal Network Associated With Psychopathic Traits in Violent Offenders With Schizophrenia.Frontiers in psychiatry · 2022Article
- Cold-Blooded and on Purpose: A Review of the Biology of Proactive Aggression.Brain sciences · 2021Review
- White matter microstructure in schizophrenia patients with a history of violence.European archives of psychiatry and clinical neuroscience · 2021Article
- White Matter Correlates of Hostility and Aggression in the Visuospatial Function Network in Patients With Schizophrenia.Frontiers in psychiatry · 2021Article
- The neural basis of hostility-related dimensions in schizophrenia.Epidemiology and psychiatric sciences · 2018Review
- Imaging Violence in Schizophrenia: A Systematic Review and Critical Discussion of the MRI Literature.Frontiers in psychiatry · 2018Article
- Structural Magnetic Resonance Imaging Correlates of Aggression in Psychosis: A Systematic Review and Effect Size Analysis.Frontiers in psychiatry · 2018Article
- Erratum to: Brain structure differences among male schizophrenic patients with history of serious violent acts: an MRI voxel-based morphometric study.BMC psychiatry · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe biological underpinnings of serious violent behaviors in patients with schizophrenia remain unclear. The aim of this study was to identify the characteristics of brain morphometry in patients with schizophrenia and a history of serious violent acts, who were being treated under relatively new legislation for offenders with mental illness in Japan where their relevant action should be strongly associated with their mental illness. We also investigated whether morphometric changes would depend on types of serious violent actions or not.
methodsThirty-four male patients with schizophrenia who were hospitalized after committing serious violent acts were compared with 23 male outpatients or inpatients with schizophrenia and no history of violent acts. T1-weighted magnetic resonance imaging (MRI) with voxel-based morphometry was used to assess gray matter volume. Additionally, patients with violent acts were divided based on whether their relevant actions were premeditated or not. The regional volumes of these two groups were compared to those of the control patient group.
resultsPatients with schizophrenia and a history of serious violent acts showed significantly smaller regional volumes of the right inferior temporal area expanded to the middle temporal gyrus and the temporal pole, and the right insular area compared to patients without a history of violence. Patients with premeditated violent acts showed significantly smaller regional volumes of the right inferior temporal area, the right insular area, the left planum polare area including the insula, and the bilateral precuneus area including the posterior cingulate gyrus than those without a history of violence, whereas patients with impulsive violent acts showed significantly smaller volumes of only the right inferior temporal area compared to those without a history of violence.
conclusionsPatients with schizophrenia and a history of serious violent acts showed structural differences in some brain regions compared to those with schizophrenia and no history of violence. Abnormalities in the right inferior temporal area were relatively common but did not depend on whether the violent actions were premeditated or not, and abnormalities in a wider range may be attributed to not only planning the violent action against others but also to maintaining that plan.
trial registrationUMIN.ac.jp UMIN000008065 . Registered 2012/05/31.
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