Evidence map›Paper›PMID 28327104›Full record

Observational studyBMC pediatrics2017

Characterizing early child growth patterns of height-for-age in an urban slum cohort of Bangladesh with functional principal component analysis.

Yin Zhang, Jianhui Zhou, Feiyang Niu, Jeffrey R Donowitz, Rashidul Haque, William A Petri, Jennie Z Ma

Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in BMC pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02734264 (Field Studies of Human Immunity to Amebiasis in Bangladesh), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02734264 completednot on this map

Field Studies of Human Immunity to Amebiasis in Bangladesh: A Prospective Study of Children Ages 0-17 Years

TypeobservationalSponsorUniversity of VirginiaRan2008 to 2014Enrolled629ConditionsAmebiasis, Cryptosporidium
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Early childhood growth in Daasanach pastoralists of Northern Kenya: Distinct patterns of faltering in linear growth and weight gain.American journal of human biology : the official journal of the Human Biology Council · 2023
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yin ZhangDepartment of Statistics, University of Virginia, Charlottesville, VA, USA.
Jianhui ZhouDepartment of Statistics, University of Virginia, Charlottesville, VA, USA.
Feiyang NiuDepartment of Statistics, University of Virginia, Charlottesville, VA, USA.
Jeffrey R DonowitzDivision of Pediatric Infectious Diseases, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA, USA.
Rashidul HaqueInternational Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), Dhaka, Bangladesh.
William A PetriDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
Jennie Z MaDepartment of Public Health Sciences, University of Virginia, P.O. Box 800717, Charlottesville, 22908, VA, USA. jzm4h@virginia.edu.
University of Virginia · USInternational Centre for Diarrhoeal Disease Research · BDVirginia Commonwealth University · US

Funding

FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
NIAID NIH HHS R01 AI043596
6 · The paper itself

Abstract

backgroundEarly childhood is a critical stage of physical and cognitive growth that forms the foundation of future wellbeing. Stunted growth is presented in one of every 4 children worldwide and contributes to developmental impairment and under-five mortality. Better understanding of early growth patterns should allow for early detection and intervention in malnutrition. We aimed to characterize early child growth patterns and quantify the change of growth curves from the World Health Organization (WHO) Child Growth Standards.

methodsIn a cohort of 626 Bangladesh children, longitudinal height-for-age z-scores (HAZ) were modelled over the first 24 months of life using functional principal component analysis (FPCA). Deviation of individual growth from the WHO standards was quantified based on the leading functional principal components (FPCs), and growth faltering was detected as it occurred. The risk factors associated with growth faltering were identified in a linear regression.

resultsNinety-eight percent of temporal variation in growth trajectories over the first 24 months of life was captured by two leading FPCs (FPC1 for overall growth and FPC2 for change in growth trajectory). A derived index, adj-FPC2, quantified the change in growth trajectory (i.e., growth faltering) relative to the WHO standards. In addition to HAZ at birth, significant risk factors associated with growth faltering in boys included duration of breastfeeding, family size and income and in girls maternal weight and water source.

conclusionsThe underlying growth patterns of HAZ in the first 2 years of life were delineated with FPCA, and the deviations from the WHO standards were quantified from the two leading FPCs. The adj-FPC2 score provided a meaningful measure of growth faltering in the first 2 years of life, which enabled us to identify the risk factors associated with poor growth that would have otherwise been missed. Understanding faltering patterns and associated risk factors are important in the development of effective intervention strategies to improve childhood growth globally.

trial registrationClinicalTrials.gov Identifier: NCT02734264 , registered 22 March, 2016.

Indexed as

Body HeightBangladeshChild, PreschoolFemaleGrowth ChartsGrowth DisordersHumansInfantInfant, NewbornLinear ModelsLongitudinal StudiesMalePrincipal Component AnalysisProspective StudiesRisk FactorsWorld Health OrganizationAnthropometryFunctional data analysisGrowth falteringLongitudinal growthStunting

Identifiers

PMID28327104
PMCPMC5359797
OpenAlexW2601735564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.