ArticleJournal of biological rhythms2017
Resynchronization Dynamics Reveal that the Ventral Entrains the Dorsal Suprachiasmatic Nucleus.
Article in Journal of biological rhythms, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Modelling the effect of V1a receptor antagonism and its potential therapeutic effect in circadian disorders.Npj biological timing and sleep · 2026Article
- Toward dissection of diverse neural components in the suprachiasmatic nucleus (SCN) pacemaker network.Neurobiology of sleep and circadian rhythms · 2026Article
- Time after time - circadian clocks through the lens of oscillator theory.FEBS letters · 2026Review
- The inferred functional connectome underlying circadian synchronization in the mouse suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Functional Connectome Mediating Circadian Synchrony in the Suprachiasmatic Nucleus.bioRxiv : the preprint server for biology · 2024Article
- The seasons within: a theoretical perspective on photoperiodic entrainment and encoding.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Synaptic reorganization of synchronized neuronal networks with synaptic weight and structural plasticity.PLoS computational biology · 2024Article
- Reduced Plasticity in Coupling Strength in the Aging SCN Clock as Revealed by Kuramoto Modeling.Journal of biological rhythms · 2023Article
- A synthetic population-level oscillator in non-microfluidic environments.Communications biology · 2023Article
- Limits of entrainment of circadian neuronal networks.Chaos (Woodbury, N.Y.) · 2023Article
- Generation and Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus: A Core-Shell Model.Journal of biological rhythms · 2022Article
- Deciphering clock cell network morphology within the biological master clock, suprachiasmatic nucleus: From the perspective of circadian wave dynamics.PLoS computational biology · 2022Article
- A spatio-temporal model to reveal oscillator phenotypes in molecular clocks: Parameter estimation elucidates circadian gene transcription dynamics in single-cells.PLoS computational biology · 2021Article
- Review
- The Excitatory Effects of GABA within the Suprachiasmatic Nucleus: Regulation of Na-K-2Cl Cotransporters (NKCCs) by Environmental Lighting Conditions.Journal of biological rhythms · 2020Article
- Molecular and Cellular Networks in The Suprachiasmatic Nuclei.International journal of molecular sciences · 2019Review
- Suprachiasmatic function in a circadian period mutant: Duper alters light-induced activation of vasoactive intestinal peptide cells and PERIOD1 immunostaining.The European journal of neuroscience · 2018Article
- Inferring dynamic topology for decoding spatiotemporal structures in complex heterogeneous networks.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Generation of circadian rhythms in the suprachiasmatic nucleus.Nature reviews. Neuroscience · 2018Review
- Measuring Relative Coupling Strength in Circadian Systems.Journal of biological rhythms · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Although the suprachiasmatic nucleus (SCN) has long been considered the master circadian clock in mammals, the topology of the connections that synchronize daily rhythms among SCN cells is not well understood. We combined experimental and computational methods to infer the directed interactions that mediate circadian synchrony between regions of the SCN. We analyzed PERIOD2 (PER2) expression from SCN slices during and after treatment with tetrodotoxin, allowing us to map connections as cells resynchronized their daily cycling following blockade and restoration of cell-cell communication. Using automated analyses, we found that cells in the dorsal SCN stabilized their periods slower than those in the ventral SCN. A phase-amplitude computational model of the SCN revealed that, to reproduce the experimental results: (1) the ventral SCN had to be more densely connected than the dorsal SCN and (2) the ventral SCN needed strong connections to the dorsal SCN. Taken together, these results provide direct evidence that the ventral SCN entrains the dorsal SCN in constant conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.