ArticleJournal of natural products2017
The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture.
Article in Journal of natural products, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 110 citations in OpenAlex.
- Structurally diverse secondary metabolites from the dung-inhabiting fungus Botryotrichum murorum.Scientific reports · 2026Article
- Berkeleylactam A-Total Synthesis andACS omega · 2026Article
- Computational Study on Potentially Active Antibacterial Compounds in Secondary Metabolites of Extremophilic Microorganisms.ChemistryOpen · 2026Article
- Fungal Coculture: Unlocking the Potential for Efficient Bioconversion of Lignocellulosic Biomass.Journal of fungi (Basel, Switzerland) · 2025Review
- Current Approaches and Implications in Discovery of Novel Bioactive Products from Microbial Sources.Current microbiology · 2025Review
- Biosynthetic Strategies of Berberine Bridge Enzyme-like Flavoprotein Oxidases toward Structural Diversification in Natural Product Biosynthesis.Biochemistry · 2024Review
- Antifungal Activity of Disalt of Epipyrone A fromJournal of fungi (Basel, Switzerland) · 2024Article
- MACROLACTONES AND MACROLIDES FROM PLANT ENDOPHYTIC FUNGI, CHEMICAL SCAFFOLDS, BIOLOGICAL ACTIVITIES AND SPECTROSCOPY: A COMPREHENSIVE REVIEW.Bulletin of pharmaceutical sciences · 2024Article
- Metabolomics-Guided Discovery of New Dimeric Xanthones from Co-Cultures of Mangrove Endophytic FungiMarine drugs · 2024Article
- Steglich esterification: A versatile synthetic approach toward the synthesis of natural products, their analogues/derivatives.Heliyon · 2024Article
- A mass spectrometry-based strategy for investigating volatile molecular interactions in microbial consortia: unveiling aFrontiers in microbiology · 2024Article
- Yamaguchi esterification: a key step toward the synthesis of natural products and their analogs-a review.Frontiers in chemistry · 2024Review
- Sporothioethers: deactivated alkyl citrates from the fungusRSC advances · 2023Article
- Beyond Penicillin: The Potential of Filamentous Fungi for Drug Discovery in the Age of Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2023Review
- The Potential Use of Fungal Co-Culture Strategy for Discovery of New Secondary Metabolites.Microorganisms · 2023Review
- Enhancing chemical and biological diversity by co-cultivation.Frontiers in microbiology · 2023Review
- Activation of cryptic biosynthetic gene clusters by fungal artificial chromosomes to produce novel secondary metabolites.AIMS microbiology · 2023Article
- Newly Discovered Mechanisms of Antibiotic Self-Resistance with Multiple Enzymes Acting at Different Locations and Stages.Antibiotics (Basel, Switzerland) · 2022Review
- Biocontrol ofAntibiotics (Basel, Switzerland) · 2022Review
- Fungal-fungal co-culture: a primer for generating chemical diversity.Natural product reports · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
A carefully timed coculture fermentation of Penicillium fuscum and P. camembertii/clavigerum yielded eight new 16-membered-ring macrolides, berkeleylactones A-H (1, 4, 6-9, 12, 13), as well as the known antibiotic macrolide A26771B (5), patulin, and citrinin. There was no evidence of the production of the berkeleylactones or A26771B (5) by either fungus when grown as axenic cultures. The structures were deduced from analyses of spectral data, and the absolute configurations of compounds 1 and 9 were determined by single-crystal X-ray crystallography. Berkeleylactone A (1) exhibited the most potent antimicrobial activity of the macrolide series, with low micromolar activity (MIC = 1-2 μg/mL) against four MRSA strains, as well as Bacillus anthracis, Streptococcus pyogenes, Candida albicans, and Candida glabrata. Mode of action studies have shown that, unlike other macrolide antibiotics, berkeleylactone A (1) does not inhibit protein synthesis nor target the ribosome, which suggests a novel mode of action for its antibiotic activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.