ReviewCurrent neurology and neuroscience reports2017
Targeted Treatment of Brain Metastases.
Review in Current neurology and neuroscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Forecasting the risk of early death among patients suffering from lung cancer with brain metastasis after radiotherapy using interpretable machine learning: a study based on the SEER database.Journal of thoracic disease · 2026Article
- Stereotactic radiosurgery practice patterns for brain metastases: a survey by the SRS_SBRT_SEOR (Spanish Society of Radiation Oncology) Working Group.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025Article
- Melanoma Cell Intrinsic GABAInternational journal of radiation oncology, biology, physics · 2021Article
- Current approaches to the management of brain metastases.Nature reviews. Clinical oncology · 2020Review
- Article
- Therapeutic management of neuro-oncologic patients - potential relevance of CSF liquid biopsy.Theranostics · 2020Article
- The impact of systemic precision medicine and immunotherapy treatments on brain metastases.Oncotarget · 2019Article
- Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacyBiomedical optics express · 2019Article
- Novel Systemic Treatments for Brain Metastases From Lung Cancer.Current treatment options in neurology · 2018Review
- Stereotactic radiosurgery practice patterns for brain metastases in the United States: a national survey.Journal of radiation oncology · 2018Article
- Foe or friend? Janus-faces of the neurovascular unit in the formation of brain metastases.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- Whole-Brain Radiotherapy for Brain Metastases: Evolution or Revolution?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Review
- Review
- Mechanisms and Therapy for Cancer Metastasis to the Brain.Frontiers in oncology · 2018Review
- Comprehensive molecular biomarker identification in breast cancer brain metastases.Journal of translational medicine · 2017Article
- Article
- Emerging strategies for delivering antiangiogenic therapies to primary and metastatic brain tumors.Advanced drug delivery reviews · 2017Review
- High αv Integrin Level of Cancer Cells Is Associated with Development of Brain Metastasis in Athymic Rats.Anticancer research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewBrain metastases are the most common intracranial tumors in adults. Historically, the median survival after the diagnosis of brain metastases has been dismal and medical therapies had a limited role in the management of these patients. RECENT
findingsThe advent of targeted therapy has ushered in an era of increased hope for patients with brain metastases. The most common malignancies that result in brain metastases-melanoma, lung cancer, and breast cancer, often have actionable mutations, which make them good candidates for targeted systemic therapy. These brain metastases have been shown to have relevant and sometimes divergent genetic alterations, and there has been a resurgence of interest in targeted drug delivery to the brain by using standard or pulsatile dosing to achieve adequate concentration in the brain. An increased understanding of oncogenic alterations, a surge in targeted drug development with good blood barrier penetration, and inclusion of patients with active brain metastases on clinical trials have led to improved outcomes for patients with brain metastases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.