Evidence map›Paper›PMID 28326445›Full record

ReviewJournal of neural transmission (Vienna, Austria : 1996)2018

The role of nonhuman primate models in the development of cell-based therapies for Parkinson's disease.

Scott C Vermilyea, Marina E Emborg

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of neural transmission (Vienna, Austria : 1996), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Parkinson's Disease: Exploring Different Animal Model Systems.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Zoological research · 2021
    Article
  6. Article
  7. Review
  8. Non-human primate research of basal ganglia and movement disorders: advances and challenges.Journal of neural transmission (Vienna, Austria : 1996) · 2018
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Scott C VermilyeaNeuroscience Training Program, University of Wisconsin, Madison, 1220 Capitol Court, Madison, WI, 53715, USA.
Marina E EmborgNeuroscience Training Program, University of Wisconsin, Madison, 1220 Capitol Court, Madison, WI, 53715, USA. emborg@primate.wisc.edu.ORCID 0000-0002-9351-6641
Oregon National Primate Research Center · USUniversity of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Individualized Cell Therapy for Parkinson's DiseaseR01NS076352 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ZHANG, SU-CHUN · 2012 to 2016
$3.1M
Transgenic marmosets for translational stem cell researchR24OD019803 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI EMBORG, MARINA, GOLOS, THADDEUS G · 2015 to 2018
$2.7M
NIH HHS P51 OD011106NIH HHS R24 OD019803NINDS NIH HHS R01 NS076352
6 · The paper itself

Abstract

Through the course of over three decades, nonhuman primate (NHP) studies on cell-based therapies (CBTs) for Parkinson's disease (PD) have provided insight into the feasibility, safety and efficacy of the approach, methods of cell collection and preparation, cell viability, as well as potential brain targets. Today, NHP research continues to be a vital source of information for improving cell grafts and analyzing how the host affects graft survival, integration and function. Overall, this article aims to discuss the role that NHP models of PD have played in CBT development and highlights specific issues that need to be considered to maximize the value of NHP studies for the successful clinical translation of CBTs.

Indexed as

AnimalsCell- and Tissue-Based TherapyDisease Models, AnimalParkinson DiseasePrimatesDopamineNonhuman primatesParkinson’s diseaseStem cells

Identifiers

PMID28326445
PMCPMC5847191
OpenAlexW2603080050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.