Evidence map›Paper›PMID 28326351›Full record

ArticleBone reports2016

Effects of low-dose ibuprofen supplementation and resistance training on bone and muscle in postmenopausal women: A randomized controlled trial.

Whitney R D Duff, Saija A Kontulainen, Darren G Candow, Julianne J Gordon, Riley S Mason, Regina Taylor-Gjevre, Bindu Nair, Michael Szafron, Adam D G Baxter-Jones, Gordon A Zello and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 5 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Exercise training and bone mineral density in postmenopausal women: an updated systematic review and meta-analysis of intervention studies with emphasis on potential moderators.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Pooled it
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  4. Effects of dynamic resistance exercise on bone mineral density in postmenopausal women: a systematic review and meta-analysis with special emphasis on exercise parameters.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Pooled it
  5. Pooled it
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  10. Emerging molecular mediators and targets for age-related skeletal muscle atrophy.Translational research : the journal of laboratory and clinical medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Whitney R D DuffCollege of Kinesiology, Physical Activity Complex, 87 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5B2, Canada.
Saija A KontulainenCollege of Kinesiology, Physical Activity Complex, 87 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5B2, Canada.
Darren G CandowFaculty of Kinesiology and Health Studies, Centre for Kinesiology, Health, and Sport, 3737 Wascana Parkway, University of Regina, Regina, SK, S4S 0A2, Canada.
Julianne J GordonCollege of Kinesiology, Physical Activity Complex, 87 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5B2, Canada.
Riley S MasonCollege of Kinesiology, Physical Activity Complex, 87 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5B2, Canada.
Regina Taylor-GjevreCollege of Medicine, Health Sciences Building Box 19, 107 Wiggins Road, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada.
Bindu NairCollege of Medicine, Health Sciences Building Box 19, 107 Wiggins Road, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada.
Michael SzafronSchool of Public Health, Health Sciences Building, 104 Clinic Place, University of Saskatchewan, Saskatoon, SK, S7N 2Z4, Canada.
Adam D G Baxter-JonesCollege of Kinesiology, Physical Activity Complex, 87 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5B2, Canada.
Gordon A ZelloCollege of Pharmacy and Nutrition, Health Sciences Building, 104 Clinic Place, University of Saskatchewan, Saskatoon, SK, S7N 2Z4, Canada.
Philip D ChilibeckCollege of Kinesiology, Physical Activity Complex, 87 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5B2, Canada.
University of Saskatchewan · CAUniversity of Regina · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the effects of nine months of exercise training and ibuprofen supplementation (given immeditately after exercise sessions) on bone and muscle in postmenopausal women.

methodsIn a double-blind randomized trial, participants (females: n = 90, mean age 64.8, SD 4.3 years) were assigned (computer generated, double blind) to receive supervised resistance training or stretching 3 days/week, and ibuprofen (400 mg, post-exercise) or placebo (i.e. 4 groups) for 9 months. In this proof-of-concept study the sample size was halved from required 200 identified via 90% power calculation. Baseline and post-intervention testing included: Dual energy x-ray absorptiometry (DXA) for lumbar spine, femoral neck, and total body areal bone mineral density (aBMD); geometry of proximal femur; total body lean tissue and fat mass; predicted 1-repetition maximum muscle strength testing (1RM; biceps curl, hack squat).

resultsExercise training or ibuprofen supplementation had no effects on aBMD of the lumbar spine, femoral neck, and total body. There was a significant exercise × supplement × time interaction for aBMD of Ward's region of the femoral neck (p = 0.015) with post hoc comparison showing a 6% decrease for stretching with placebo vs. a 3% increase for stretching with ibuprofen (p = 0.017). Resistance training increased biceps curl and hack squat strength vs. stretching (22% vs. 4% and 114% vs. 12%, respectively) (p < 0.01) and decreased percent body fat compared to stretching (2% vs. 0%) (p < 0.05).

conclusionsIbuprofen supplementation provided some benefits to bone when taken independent of exercise training in postmenopausal women. This study provides evidence towards a novel, easily accessible stimulus for enhancing bone health [i.e. ibuprofen].

Indexed as

AgingIbuprofenOsteoporosisSarcopenia

Identifiers

PMID28326351
PMCPMC4926836
OpenAlexW2343231306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.