ArticleBone reports2016
Tumor induced osteomalacia secondary to anaplastic thyroid carcinoma: A case report and review of the literature.
Article in Bone reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Tumor-induced Osteomalacia: A Case Report and Etiological Analysis with Literature Review.Orthopaedic surgery · 2023Review
- [Clinical features, diagnostics and treatment of FGF23 secreting tumors: series of 40 clinical cases].Problemy endokrinologii · 2023Article
- Unusual phosphaturic mesenchymal tumor mimicking osteoid osteoma.Radiology case reports · 2023Article
- Anaplastic thyroid carcinoma: Updates on WHO classification, clinicopathological features and staging.Histology and histopathology · 2021Review
- Tumor-Induced Osteomalacia.Calcified tissue international · 2021Review
- Role of Fibroblast Growth Factor 23 (FGF23) and αKlotho in Cancer.Frontiers in cell and developmental biology · 2020Review
- Metastatic prostate cancer presenting as tumour-induced osteomalacia.BMJ case reports · 2019Article
- Oncogenic osteomalacia and metastatic breast cancer: a case report and review of the literature.Journal of diabetes and metabolic disorders · 2019Article
- Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets/osteomalacia (TIO).Bone reports · 2019Article
- Phosphaturic mesenchymal tumors: what an endocrinologist should know.Journal of endocrinological investigation · 2018Review
- Fibroblast Growth Factor 23-Induced Hypophosphatemia in Acute Leukemia.Journal of the Endocrine Society · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextTumor induced osteomalacia related to anaplastic thyroid cancer has never been reported.
objectiveWe describe a case of tumor induced osteomalacia (TIO) in a patient with a fibroblast growth factor 23 (FGF-23) secreting anaplastic thyroid carcinoma. The current imaging modalities are reviewed. DESIGN AND
interventionClinical, biochemical, and radiological assessments were done, including computer tomography (CT) of the neck and skull to thigh positron emission tomography (PET)/CT. The patient underwent surgical tumor debulking three days after presentation due to airway compromise. Molecular studies of the resected tissue were performed using reverse transcriptase-polymerase chain reaction (RT-PCR) and gel electrophoresis for the phosphaturic mesenchymal tumor FGF-23.
resultsResected tissue demonstrated features of anaplastic thyroid cancer with positive markers for FGF-23 protein, consistent with a FGF-23 secreting paraneoplastic tumor. The patient's metastatic burden rapidly progressed as demonstrated by a dramatic rise in serum FGF-23 levels and worsening hypophosphatemia in concert with progression of the metastatic lesions on PET/CT.
conclusionWe believe that our patient's rapidly progressive anaplastic thyroid cancer was responsible for persistent hypophosphatemia and osteomalacia, substantiated by the finding of FGF-23 protein within the thyroid tumor cells. Our case indicates that anaplastic thyroid cancer can cause TIO.
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