ReviewJournal of bone metabolism2017
Role of the Cytokine-like Hormone Leptin in Muscle-bone Crosstalk with Aging.
Review in Journal of bone metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- MicroRNAs in Sarcopenia: A Systematic Review.Frontiers in medicine · 2020Pooled it
- Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention.Journal of cachexia, sarcopenia and muscle · 2019Trial
- Impact of Hepatic Steatosis, Psoas Muscle Mass, and Density on Outcomes in Patients with Moderately Severe and Severe Acute Pancreatitis: A Serial Computed Tomography-Based Retrospective Study.The Indian journal of radiology & imaging · 2025Article
- Exploring the Relationship Among Malnutrition, Intake of Various Food Groups, and Sarcopenia in Elderly Population: A Cross-Sectional Analysis.Health science reports · 2025Article
- Cluster analysis of sarcopenia in older adults: significant factors contributing to disease severity.European geriatric medicine · 2025Article
- Cancer Cachexia.Advances in experimental medicine and biology · 2025Review
- Metabolic score tool for personalized acute pancreatitis prognosis: A multicenter analysis.Biomolecules & biomedicine · 2024Article
- Sarcopenic obesity in cancer.Radiology and oncology · 2024Review
- Landscape and research trends of sarcopenic obesity research: A bibliometric analysis.Heliyon · 2024Review
- Dissecting the importance and origin of circulating myokines in gastric cancer cachexia.Frontiers in endocrinology · 2024Article
- Changes of the posterior paraspinal and psoas muscle in patients with low back pain: a 3-year longitudinal study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Effects of aging-induced obesity on the transcriptional expression of adipogenesis and thermogenic activity in the gonadal white adipose, brown adipose, and skeletal muscle tissues.Physical activity and nutrition · 2023Article
- Sex-specific alteration in human muscle transcriptome with age.GeroScience · 2023Article
- Sarcopenia and Sarcopenic Obesity and Osteoarthritis: A Discussion among Muscles, Fat, Bones, and Aging.Life (Basel, Switzerland) · 2023Review
- Myoblast-derived exosomal Prrx2 attenuates osteoporosis via transcriptional regulation of lncRNA-MIR22HG to activate Hippo pathway.Molecular medicine (Cambridge, Mass.) · 2023Article
- Probing microstructural changes in muscles of leptin-deficient zebrafish by non-invasive ex-vivo magnetic resonance microimaging.PloS one · 2023Article
- [Mibefradil improves skeletal muscle mass, function and structure in obese mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Sarcopenic Obesity: An Emerging Public Health Problem.Aging and disease · 2022Article
- DNA Methylation Modulates Aging Process in Adipocytes.Aging and disease · 2022Review
- Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors.Frontiers in endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The cytokine-like hormone leptin is a classic adipokine that is secreted by adipocytes, increases with weight gain, and decreases with weight loss. Additional studies have, however, shown that leptin is also produced by skeletal muscle, and leptin receptors are abundant in both skeletal muscle and bone-derived mesenchymal (stromal) stem cells. These findings suggest that leptin may play an important role in muscle-bone crosstalk. Leptin treatment
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.