Evidence map›Paper›PMID 28326170›Full record

ArticleJournal of extracellular vesicles2017

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper.

Bogdan Mateescu, Emma J K Kowal, Bas W M van Balkom, Sabine Bartel, Suvendra N Bhattacharyya, Edit I Buzás, Amy H Buck, Paola de Candia, Franklin W N Chow, Saumya Das and 26 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 475 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
475citing papers in PubMed, 3 pooled it
34.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

475 citing papers in PubMed, 3 syntheses or guidelines pooled it, 702 citations in OpenAlex.

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415 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 20 institutions in 17 countries.

Bogdan MateescuDepartment of Biology, Swiss Federal Institute of Technology Zurich (ETH Zürich) , Zurich , Switzerland.
Emma J K KowalDepartment of Biology, Massachusetts Institute of Technology , Cambridge , MA , USA.ORCID 0000-0002-8992-7608
Bas W M van BalkomDepartment of Nephrology and Hypertension, UMC Utrecht , Utrecht , the Netherlands.
Sabine BartelExperimental Asthma Research, Priority Area Asthma & Allergy, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL) , Borstel , Germany.
Suvendra N BhattacharyyaDepartment of Science and Technology, CSIR-Indian Institute of Chemical Biology , Kolkata , India.
Edit I BuzásDepartment of Genetics, Cell- and Immunobiology, Semmelweis University , Budapest , Hungary.
Amy H BuckInstitute of Immunology and Infection Research, Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh , Edinburgh , UK.
Paola de CandiaIRCCS MultiMedica , Milan , Italy.
Franklin W N ChowInstitute of Immunology and Infection Research, Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh , Edinburgh , UK.
Saumya DasCardiovascular Research Institute, Massachusetts General Hospital , Boston , MA , USA.
Tom A P DriedonksDepartment of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University , Utrecht , the Netherlands.
Lola Fernández-MessinaImmunology Service, Hospital La Princesa , Madrid , Spain.
Franziska HaderkDepartment of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Medicine, Helen Diller Family Comprehensive Cancer Center, UC San Francisco, San Francisco, CA, USA.
Andrew F HillDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University , Bundoora , Australia.ORCID 0000-0001-5581-2354
Jennifer C JonesMolecular Immunogenetics & Vaccine Research Section, Vaccine Branch, CCR, NCI , Bethesda , MD , USA.ORCID 0000-0002-9488-7719
Kendall R Van Keuren-JensenNeurogenomics Division, TGen , Phoenix , AZ , USA.
Charles P LaiInstitute of Biomedical Engineering, National Tsing Hua University , Hsinchu , Taiwan.
Cecilia LässerDepartment of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and NeuroDiscovery Center, Harvard Medical School, Boston, MA, USA; Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Italia di LiegroDepartment of Experimental Biomedicine and Clinical Neurosciences (BIONEC), University of Palermo , Palermo , Italy.
Taral R LunavatDepartment of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and NeuroDiscovery Center, Harvard Medical School, Boston, MA, USA; Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Magdalena J LorenowiczCenter for Molecular Medicine, University Medical Center Utrecht & Regenerative Medicine Center , Utrecht , the Netherlands.
Sybren L N MaasDepartment of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and NeuroDiscovery Center, Harvard Medical School , Boston , MA , USA.
Imre MägerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK; Institute of Technology, University of Tartu, Tartu, Estonia.
Maria MittelbrunnInstituto de Investigación del Hospital 12 de Octubre , Madrid , Spain.
Stefan MommaInstitute of Neurology (Edinger Institute), Frankfurt University Medical School , Frankfurt am Main , Germany.
Kamalika MukherjeeDepartment of Science and Technology, CSIR-Indian Institute of Chemical Biology , Kolkata , India.
Muhammed NawazDepartment of Pathology and Forensic Medicine, Ribeirão Preto School of Medicine, University of Sao Paulo , Sao Paulo , Brazil.
D Michiel PegtelDepartment of Pathology, Exosomes Research Group, VU University Medical Center , Amsterdam , the Netherlands.
Michael W PfafflAnimal Physiology and Immunology, School of Life Sciences, Technical University of Munich (TUM) Weihenstephan , Freising , Germany.
Raymond M SchiffelersLaboratory Clinical Chemistry & Haematology, University Medical Center Utrecht , Utrecht , the Netherlands.
Hidetoshi TaharaDepartment of Cellular and Molecular Biology, Institute of Biomedical & Health Sciences, Hiroshima University , Hiroshima , Japan.
Clotilde ThéryInstitut Curie, PSL Research University, INSERM U932 , Paris , France.
Juan Pablo TosarFunctional Genomics Unit, Institut Pasteur de Montevideo, Nuclear Research Center, Faculty of Science, Universidad de la República , Montevideo , Uruguay.
Marca H M WaubenDepartment of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University , Utrecht , the Netherlands.
Kenneth W WitwerDepartment of Molecular and Comparative Pathobiology and Department of Neurology, The Johns Hopkins University School of Medicine , Baltimore , MD , USA.ORCID 0000-0003-1664-4233
Esther N M Nolte-'t HoenDepartment of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University , Utrecht , the Netherlands.
Harvard University · USUniversity Medical Center Utrecht · NLUniversity of Applied Sciences Utrecht · NLCentre for Immunity, Infection and Evolution · GBIndian Institute of Chemical Biology · INAmsterdam UMC Location Vrije Universiteit Amsterdam · NLETH Zurich · CHGerman Cancer Research Center · DEGoethe University Frankfurt · DEHiroshima University · JPHospital Universitario de La Princesa · ESInserm · FRInstitut de Recherche Vaccinale · FRJohns Hopkins University · USLa Trobe University · AUMassachusetts General Hospital · USMassachusetts Institute of Technology · USMultiMedica · ITNational Tsing Hua University · TWResearch Center Borstel - Leibniz Lung Center · DE

Funding

SidTI/2-dependent EC-RNA Biogenesis and UptalceU19CA179513 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCMANUS, MICHAEL T · 2013 to 2017
$8.3M
Novel Combinations of Radiation and ImmunotherapyZIABC011503 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2013 to 2025
$5.3M
Plasma miRNA predictors of adverse mechanical and electrical remodeling after MIUH3TR000901 · NCATS · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA, KWONG, RAYMOND Y · 2015 to 2017
$3.2M
Novel Role for Circulating extracellular RNAs in Human Heart FailureR01HL122547 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA · 2015 to 2019
$2.1M
NCATS NIH HHS UH3 TR000901NCI NIH HHS U19 CA179513NHLBI NIH HHS R01 HL122547
6 · The paper itself

Abstract

The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has been demonstrated in a multitude of different

Indexed as

exosomesExtracellular vesiclesfunctionmRNAnon-coding RNAquantificationRNA binding proteinssorting

Identifiers

PMID28326170
PMCPMC5345583
OpenAlexW2593629244

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.