Evidence map›Paper›PMID 28326105›Full record

ArticleStem cells international2017

Paracrine Effects of Bone Marrow Mononuclear Cells in Survival and Cytokine Expression after 90% Partial Hepatectomy.

Carlos Oscar Kieling, Carolina Uribe-Cruz, Mónica Luján López, Alessandro Bersch Osvaldt, Themis Reverbel da Silveira, Ursula Matte

Open access · goldAbstract read
In one paragraph

Article in Stem cells international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Carlos Oscar KielingExperimental Laboratory of Gastroenterology and Hepatology, HCPA, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Post-Graduation Program on Medicine: Sciences in Gastroenterology, UFRGS, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil.
Carolina Uribe-CruzExperimental Laboratory of Gastroenterology and Hepatology, HCPA, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Post-Graduation Program on Medicine: Sciences in Gastroenterology, UFRGS, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Gene Therapy Center, HCPA, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil.
Mónica Luján LópezGene Therapy Center, HCPA, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Post-Graduation Program on Genetics and Molecular Biology, UFRGS, Av. Bento Gonçalves 9500, 91501-970 Porto Alegre, RS, Brazil.
Alessandro Bersch OsvaldtPost-Graduation Program in Surgery, UFRGS, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil.
Themis Reverbel da SilveiraExperimental Laboratory of Gastroenterology and Hepatology, HCPA, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Post-Graduation Program on Medicine: Sciences in Gastroenterology, UFRGS, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil.
Ursula MatteGene Therapy Center, HCPA, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Post-Graduation Program on Genetics and Molecular Biology, UFRGS, Av. Bento Gonçalves 9500, 91501-970 Porto Alegre, RS, Brazil; Post-Graduation Program in Child and Adolescent Health, UFRGS, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil.ORCID 0000-0003-4977-6662
Universidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute liver failure is a complex and fatal disease. Cell-based therapies are a promising alternative therapeutic approach for liver failure due to relatively simple technique and lower cost. The use of semipermeable microcapsules has become an interesting tool for evaluating paracrine effects in vivo. In this study, we aimed to assess the paracrine effects of bone marrow mononuclear cells (BMMC) encapsulated in sodium alginate to treat acute liver failure in an animal model of 90% partial hepatectomy (90% PH). Encapsulated BMMC were able to increase 10-day survival without enhancing liver regeneration markers. Gene expression of

Identifiers

PMID28326105
PMCPMC5343266
OpenAlexW2589600738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.