ReviewFrontiers in neuroanatomy2017
Pyramidal Neurons Are Not Generalizable Building Blocks of Cortical Networks.
Review in Frontiers in neuroanatomy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 87 citations in OpenAlex.
- NMDA receptor mediated tonic excitatory currents are elicited by EAAT inhibition on human neocortical pyramidal neurons.Frontiers in synaptic neuroscience · 2026Article
- Impacts of CACNB4 overexpression on dendritic spine density in both sexes and relevance to schizophrenia.Translational psychiatry · 2024Article
- Areal specializations in the morpho-electric and transcriptomic properties of primate layer 5 extratelencephalic projection neurons.Cell reports · 2024Article
- Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17.Brain structure & function · 2024Article
- Signatures of hierarchical temporal processing in the mouse visual system.PLoS computational biology · 2024Article
- Key morphological features of human pyramidal neurons.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Structural changes of CA1 pyramidal neurons after stroke in the contralesional hippocampus.Brain pathology (Zurich, Switzerland) · 2024Article
- Dynamic fading memory and expectancy effects in the monkey primary visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Understanding the genetic mechanisms and cognitive impairments in Down syndrome: towards a holistic approach.Journal of neurology · 2024Review
- Comparative features of calretinin, calbindin, and parvalbumin expressing interneurons in mouse and monkey primary visual and frontal cortices.The Journal of comparative neurology · 2023Article
- Cortical origin of theta error signals.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Transcriptomic cytoarchitecture reveals principles of human neocortex organization.Science (New York, N.Y.) · 2023Article
- Comparative Features of Calretinin, Calbindin and Parvalbumin Expressing Interneurons in Mouse and Monkey Primary Visual and Frontal Cortices.bioRxiv : the preprint server for biology · 2023Article
- Morphological Features of Human Dendritic Spines.Advances in neurobiology · 2023Review
- Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability.Cellular and molecular neurobiology · 2022Article
- Variation in Pyramidal Cell Morphology Across the Human Anterior Temporal Lobe.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Postnatal Development of Glutamate and GABA Transcript Expression in Monkey Visual, Parietal, and Prefrontal Cortices.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Learning Invariant Object and Spatial View Representations in the Brain Using Slow Unsupervised Learning.Frontiers in computational neuroscience · 2021Review
- Nonlinear Dendritic Coincidence Detection for Supervised Learning.Frontiers in computational neuroscience · 2021Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
A key challenge in cortical neuroscience is to gain a comprehensive understanding of how pyramidal neuron heterogeneity across different areas and species underlies the functional specialization of individual neurons, networks, and areas. Comparative studies have been important in this endeavor, providing data relevant to the question of which of the many inherent properties of individual pyramidal neurons are necessary and sufficient for species-specific network and areal function. In this mini review, the importance of pyramidal neuron structural properties for signaling are outlined, followed by a summary of our recent work comparing the structural features of mouse (C57/BL6 strain) and rhesus monkey layer 3 (L3) pyramidal neurons in primary visual and frontal association cortices and their implications for neuronal and areal function. Based on these and other published data, L3 pyramidal neurons plausibly might be considered broadly "generalizable" from one area to another in the mouse neocortex due to their many similarities, but major differences in the properties of these neurons in diverse areas in the rhesus monkey neocortex rules this out in the primate. Further, fundamental differences in the dendritic topology of mouse and rhesus monkey pyramidal neurons highlight the implausibility of straightforward scaling and/or extrapolation from mouse to primate neurons and cortical networks.
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