ArticleScientific reports2017
A permanent host shift of rabies virus from Chiroptera to Carnivora associated with recombination.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Key Factors That Enable the Pandemic Potential of RNA Viruses and Inter-Species Transmission: A Systematic Review.Viruses · 2021Pooled it
- Differences in codon usage between host-species-specific rabies virus clades are driven by non-GC3 nucleotide composition.Virus evolution · 2026Article
- Intrasegmental recombination as an evolutionary force of Lassa fever virus.Frontiers in microbiology · 2024Article
- Evolution and divergence of the genetic lineage Desmodus rotundus/Artibeus lituratus of rabies virus in São Paulo State.Archives of virology · 2023Article
- Consequences of Genetic Recombination on Protein Folding Stability.Journal of molecular evolution · 2023Article
- The recombinogenic history of turnip mosaic potyvirus reveals its introduction to Japan in the 19th century.Virus evolution · 2022Article
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- Using host traits to predict reservoir host species of rabies virus.PLoS neglected tropical diseases · 2020Article
- Bat-borne virus diversity, spillover and emergence.Nature reviews. Microbiology · 2020Review
- Non-vector-borne transmission of lumpy skin disease virus.Scientific reports · 2020Article
- Update on lyssaviruses and rabies: will past progress play as prologue in the near term towards future elimination?Faculty reviews · 2020Review
- Evaluation of rabies virus characterization to enhance early detection of important rabies epizootic events in the United States.Journal of the American Veterinary Medical Association · 2020Article
- Genome analysis of Ranavirus frog virus 3 isolated from American Bullfrog (Lithobates catesbeianus) in South America.Scientific reports · 2019Article
- The matrix segment of the "Spanish flu" virus originated from intragenic recombination between avian and human influenza A viruses.Transboundary and emerging diseases · 2019Article
- Evidence for Cross-Species Transmission of Covert Mortality Nodavirus to New Host ofFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bat virus host shifts can result in the spread of diseases with significant effects. The rabies virus (RABV) is able to infect almost all mammals and is therefore a useful model for the study of host shift mechanisms. Carnivore RABVs originated from two historical host shifts from bat viruses. To reveal the genetic pathways by which bat RABVs changed their host tropism from bats to carnivores, we investigated the second permanent bat-to-carnivore shift resulting in two carnivore variants, known as raccoon RABV (RRV) and south-central skunk RABV (SCSKV). We found that their glycoprotein (G) genes are the result of recombination between an American bat virus and a carnivore virus. This recombination allowed the bat RABV to acquire the head of the G-protein ectodomain of the carnivore virus. This region is involved in receptor recognition and binding, response to changes in the pH microenvironment, trimerization of G proteins, and cell-to-cell transmission during the viral infection. Therefore, this recombination event may have significantly improved the variant's adaptability to carnivores, altering its host tropism and thus leading to large-scale epidemics in striped skunk and raccoon.
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