Evidence map›Paper›PMID 28325894›Full record

ArticleScientific reports2017

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.

Mourad Ferdaoussi, Jianyang Fu, Xiaoqing Dai, Jocelyn E Manning Fox, Kunimasa Suzuki, Nancy Smith, Gregory Plummer, Patrick E MacDonald

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Metabolic and Molecular Amplification of Insulin Secretion.Advances in anatomy, embryology, and cell biology · 2024
    Review
  5. Article
  6. Regulation of insulin secretion by the post-translational modifications.Frontiers in cell and developmental biology · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. The insulin centennial-100 years of milestones in biochemistry.The Journal of biological chemistry · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. 20 Years of Secretagogin: Exocytosis and Beyond.Frontiers in molecular neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mourad FerdaoussiAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2R3, Canada. ferdaous@ualberta.ca.
Jianyang FuAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2R3, Canada.
Xiaoqing DaiAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2R3, Canada.
Jocelyn E Manning FoxAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2R3, Canada.
Kunimasa SuzukiAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2R3, Canada.
Nancy SmithAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2R3, Canada.
Gregory PlummerAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2R3, Canada.
Patrick E MacDonaldAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2R3, Canada. pmacdonald@ualberta.ca.
University of Alberta · CA

Funding

CIHR
6 · The paper itself

Abstract

Insulin secretion from pancreatic ß cells is a multistep process that requires the coordination of exocytotic proteins that integrate diverse signals. These include signals derived from metabolic control of post-translational SUMOylation and depolarization-induced rises in intracellular Ca

Indexed as

SumoylationCalciumCells, CulturedExocytosisHumansInsulinInsulin-Secreting CellsInsulin SecretionNerve Tissue ProteinsR-SNARE ProteinsSecretagoginsSyntaxin 1CalciumInsulinNerve Tissue ProteinsR-SNARE ProteinsSCGN protein, humanSecretagoginsSTXBP5 protein, humanSyntaxin 1

Identifiers

PMID28325894
PMCPMC5428262
OpenAlexW2620880484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.