ArticleAging2017
Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice.
Article in Aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Frailty, polypharmacy, deprescribing, and 23-hour activity: insights from a mouse model.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Dynamic changes in mitochondrial function in brain cortex synaptosomes during aging.Journal of bioenergetics and biomembranes · 2026Article
- Analysis of the current state of frailty indexes and their implementation for aging intervention studies.Aging · 2025Review
- The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice.GeroScience · 2025Article
- Ginkgolide B increases healthspan and lifespan of female mice.Nature aging · 2025Article
- Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer's disease.Nature communications · 2024Article
- The intersection of frailty and metabolism.Cell metabolism · 2024Review
- Protein restriction slows the development and progression of Alzheimer's disease in mice.Research square · 2024Article
- Biological aging of two innate behaviors of Drosophila melanogaster: Escape climbing versus courtship learning and memory.PloS one · 2024Article
- How is Big Data reshaping preclinical aging research?Lab animal · 2023Review
- Immune Dysfunction from Radiation Exposure.Radiation research · 2023Article
- Immune Dysfunction from Radiation Exposure.Radiation research · 2023Article
- Association of remnant cholesterol with frailty: findings from observational and Mendelian randomization analyses.Lipids in health and disease · 2023Observational
- Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice.GeroScience · 2023Article
- Unsupervised learning of aging principles from longitudinal data.Nature communications · 2022Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Development of infrastructure for a systemic multidisciplinary approach to study aging in retired sled dogs.Aging · 2021Article
- A comprehensive analysis of immune infiltration in the tumor microenvironment of osteosarcoma.Cancer medicine · 2021Article
- Late-life intermittent fasting decreases aging-related frailty and increases renal hydrogen sulfide production in a sexually dimorphic manner.GeroScience · 2021Article
- The degree of frailty as a translational measure of health in aging.Nature aging · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The development of healthspan-extending pharmaceuticals requires quantitative estimation of age-related progressive physiological decline. In humans, individual health status can be quantitatively assessed by means of a
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.