Evidence map›Paper›PMID 28325874›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporter.

Chan Cao, Shuqing Wang, Tanxing Cui, Xun-Cheng Su, James J Chou

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. MCU-i4, a mitochondrial CaOncology research · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Mitochondrial calcium cycling in neuronal function and neurodegeneration.Frontiers in cell and developmental biology · 2023
    Review
  10. Review
  11. Structural basis of CaBMB reports · 2022
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Pharmacological inhibition of the mitochondrial CaJournal of molecular and cellular cardiology · 2021
    Review
  19. Different Sensitivity of Control and MICU1- and MICU2-AblatedInternational journal of molecular sciences · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Chan CaoDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Shuqing WangSchool of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Tanxing CuiDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Xun-Cheng SuState Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China; xunchengsu@nankai.edu.cn james_chou@hms.harvard.edu.
James J ChouDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; xunchengsu@nankai.edu.cn james_chou@hms.harvard.edu.
Harvard University · USCollaborative Innovation Center of Chemical Science and Engineering Tianjin · CNNankai University · CNTianjin Medical University · CN

Funding

OverallP41EB002026 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFIN, ROBERT GUY · 2003 to 2018
$17.9M
Molecular Architecture Of The Mitochondrial Calcium UniporterR01HL130143 · NHLBI · HARVARD MEDICAL SCHOOL · PI CHOU, JAMES JEIWEN, MOOTHA, VAMSI KRISHNA · 2017 to 2020
$3.2M
Function and mechanism of the HCV p7 channel and its therapeutic potentialR01GM116898 · NIGMS · HARVARD MEDICAL SCHOOL · PI CHOU, JAMES JEIWEN · 2016 to 2019
$1.9M
NHLBI NIH HHS R01 HL130143NIBIB NIH HHS P41 EB002026NIGMS NIH HHS R01 GM116898
6 · The paper itself

Abstract

The calcium (Ca

Indexed as

Amino Acid MotifsBinding SitesCaenorhabditis elegans ProteinsCalciumMagnetic Resonance SpectroscopyManganeseMitochondrial Membrane Transport ProteinsMolecular Dynamics SimulationMutationRuthenium CompoundsCaenorhabditis elegans ProteinsCalciumManganeseMcu-1 protein, C elegansMitochondrial Membrane Transport ProteinsRu 360Ruthenium Compoundscalcium channelMCUNMRRu360 bindingselectivity filter

Identifiers

PMID28325874
PMCPMC5389301
OpenAlexW2603488123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.