Evidence map›Paper›PMID 28325790›Full record

ArticlePhysiological reports2017

Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex.

William C Buchta, Stephen V Mahler, Benjamin Harlan, Gary S Aston-Jones, Arthur C Riegel

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. KAddiction biology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Anxiety and depression: A top-down, bottom-up model of circuit function.Annals of the New York Academy of Sciences · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Distinct Role of Dopamine in the PFC and NAc During Exposure to Cocaine-Associated Cues.The international journal of neuropsychopharmacology · 2021
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. [The Journal of pharmacology and experimental therapeutics · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

William C BuchtaDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina.
Stephen V MahlerDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina.
Benjamin HarlanDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina.
Gary S Aston-JonesDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina.
Arthur C RiegelDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina riegel@musc.edu.ORCID http://orcid.org/0000-0001-7758-4436
Medical University of South Carolina · US

Funding

Selective Restoration of KCNQ Channel Inhibition in the PFC to Inhibit Cue-InducP50DA015369 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KALIVAS, PETER W · 2003 to 2017
$18.6M
DRUG ABUSE TRAINING PROGRAMT32DA007288 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Christopher W Cowan, Rachel Penrod-Martin · 1991 to 2026
$11.8M
ROLE OF OREXIN IN COCAINE DEMAND AND ADDICTIONR01DA006214 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI ASTON-JONES, GARY S. · 1989 to 2024
$6.0M
Role of Extended Amygdala in Opiate and Cocaine AbuseR37DA006214 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI ASTON-JONES, GARY S. · 2003 to 2012
$4.2M
Relapse to Cocaine-Seeking: Cellular Adaptations in the Ventral Tegmental AreaR01DA033342 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RIEGEL, ARTHUR C · 2012 to 2017
$1.5M
Role of Ventral Pallidum Projection to VTA in Reinstatement of Cocaine SeekingR00DA035251 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MAHLER, STEPHEN VINCENT · 2015 to 2017
$756k
Restoration of Intrinsic Inhibition in the PFC to Prevent Relapse to Cocaine SeekF31DA036989 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BUCHTA, WILLIAM CHRISTOPHER · 2014 to 2016
$112k
NIDA NIH HHS F31 DA036989NIDA NIH HHS P50 DA015369NIDA NIH HHS R00 DA035251NIDA NIH HHS R01 DA006214NIDA NIH HHS R01 DA033342NIDA NIH HHS R37 DA006214NIDA NIH HHS T32 DA007288
6 · The paper itself

Abstract

Spike frequency adaptation (SFA or accommodation) and calcium-activated potassium channels that underlie after-hyperpolarization potentials (AHP) regulate repetitive firing of neurons. Precisely how neuromodulators such as dopamine from the ventral tegmental area (VTA) regulate SFA and AHP (together referred to as

Indexed as

Action PotentialsAnimalsCocaineDopamineDopamine Uptake InhibitorsMaleNeural InhibitionNeural PathwaysPrefrontal CortexPyramidal CellsRatsRats, Sprague-DawleyRats, TransgenicVentral Tegmental AreaCocaineDopamineDopamine Uptake InhibitorsDREADDsoptogeneticsprefrontal cortexventral tegmental area

Identifiers

PMID28325790
PMCPMC5371565
OpenAlexW2600363486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.