Evidence map›Paper›PMID 28325789›Full record

ArticlePhysiological reports2017

Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain.

Abdel Rahman M Khalifa, Engy A Abdel-Rahman, Ali M Mahmoud, Mohamed H Ali, Maha Noureldin, Saber H Saber, Mahmoud Mohsen, Sameh S Ali

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 151 citations in OpenAlex.

  1. Article
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  10. Article
  11. Review
  12. Article
  13. Increased Intermembrane Space [CaCirculation research · 2025
    Article
  14. Sex dimorphism and substrate dependency of liver mitochondrial bioenergetics and HAmerican journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  15. Mechano-energetic uncoupling in heart failure.Nature reviews. Cardiology · 2025
    Review
  16. Article
  17. Sex-Specific Differences in LPS-Induced Rapid Myocardial Dysfunction.International journal of molecular sciences · 2025
    Article
  18. Article
  19. Article
  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Abdel Rahman M KhalifaCenter for Aging and Associated Diseases, Helmy Institute of Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Engy A Abdel-RahmanCenter for Aging and Associated Diseases, Helmy Institute of Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Ali M MahmoudCenter for Aging and Associated Diseases, Helmy Institute of Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Mohamed H AliCenter for Aging and Associated Diseases, Helmy Institute of Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Maha NoureldinCenter for Aging and Associated Diseases, Helmy Institute of Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Saber H SaberCenter for Aging and Associated Diseases, Helmy Institute of Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Mahmoud MohsenCenter for Aging and Associated Diseases, Helmy Institute of Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Sameh S AliCenter for Aging and Associated Diseases, Helmy Institute of Medical Sciences, Zewail City of Science and Technology, Giza, Egypt Sameh.ali@zewailcity.edu.eg.
Zewail City of Science and Technology · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex-specific differences in mitochondrial function and free radical homeostasis are reported in the context of aging but not well-established in pathogeneses occurring early in life. Here, we examine if sex disparity in mitochondria function, morphology, and redox status starts early and hence can be implicated in sexual dimorphism in cardiac as well as neurological disorders prevalent at young age. Although mitochondrial activity in the heart did not significantly vary between sexes, female brain exhibited enhanced respiration and higher reserve capacity. This was associated with lower H

Indexed as

Organelle BiogenesisSex CharacteristicsAgingAnimalsBrainFemaleHomeostasisMaleMiceMitochondriaMitochondria, HeartMyocardiumNADPH OxidasesOxidation-ReductionOxygen ConsumptionReactive Oxygen SpeciesNADPH OxidasesReactive Oxygen SpeciesSuperoxidesBrainEPRheartmitochondriaNADPH OxidaseROSSexsuperoxide dismutase

Identifiers

PMID28325789
PMCPMC5371549
OpenAlexW2599149063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.