Evidence map›Paper›PMID 28325762›Full record

ArticlemBio2017

A Genetic Screen Reveals that Synthesis of 1,4-Dihydroxy-2-Naphthoate (DHNA), but Not Full-Length Menaquinone, Is Required for

Grischa Y Chen, Courtney E McDougal, Marc A D'Antonio, Jonathan L Portman, John-Demian Sauer

Abstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The role ofJournal of bacteriology · 2024
    Article
  6. Infection and immunity · 2023
    Article
  7. Article
  8. bioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. eLife · 2022
    Article
  11. Article
  12. Allosteric regulation of menaquinone (vitamin KThe Journal of biological chemistry · 2020
    Article
  13. Article
  14. Article
  15. 25Journal of bacteriology · 2019
    Review
  16. Review
  17. Article
  18. Microbiology spectrum · 2018
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Grischa Y ChenDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Courtney E McDougalDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Marc A D'AntonioDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jonathan L PortmanGraduate Group in Infectious Diseases and Immunity, School of Public Health, University of California Berkeley, Berkeley, California, USA.
John-Demian SauerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA sauer3@wisc.edu.ORCID 0000-0001-9367-794X

Funding

Vaccines and Therapies Against BotulismU54AI057153 · NIAID · UNIVERSITY OF CHICAGO · PI SCHNEEWIND, OLAF · 2003 to 2013
$87.6M
Microbial Pathogenesis &Host Responses Training ProgramT32AI055397 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2003 to 2024
$5.5M
Modulating the Inflammasome to Generate Robust Cell Mediated ImmunityR01CA188034 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SAUER, JOHN-DEMIAN · 2015 to 2019
$1.7M
NCI NIH HHS R01 CA188034NIAID NIH HHS T32 AI055397NIAID NIH HHS U54 AI057153
6 · The paper itself

Abstract

Through unknown mechanisms, the host cytosol restricts bacterial colonization; therefore, only professional cytosolic pathogens are adapted to colonize this host environment.

Indexed as

Microbial ViabilityDNA Transposable ElementsGenetic TestingListeria monocytogenesMetabolic Networks and PathwaysMutagenesis, InsertionalMutationNaphtholsVitamin K 21,4-dihydroxy-2-naphthoic acidDNA Transposable ElementsNaphtholsVitamin K 2cell autonomous defensecytosolic pathogeninflammasomeListeria monocytogenesmenaquinonenutritional immunityrespiration

Identifiers

PMID28325762
PMCPMC5362031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.