Evidence map›Paper›PMID 28325749›Full record

ArticleGenetics2017

The NCA-1 and NCA-2 Ion Channels Function Downstream of G

Irini Topalidou, Pin-An Chen, Kirsten Cooper, Shigeki Watanabe, Erik M Jorgensen, Michael Ailion

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Rho signaling promotes cell excitability and synaptic transmission.bioRxiv : the preprint server for biology · 2025
    Article
  3. NALCN Channels Are Not Major targets of GαmicroPublication biology · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Irini TopalidouDepartment of Biochemistry, University of Washington, Seattle, Washington 98195.
Pin-An ChenHoward Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City, Utah 84112.
Kirsten CooperDepartment of Biochemistry, University of Washington, Seattle, Washington 98195.
Shigeki WatanabeHoward Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City, Utah 84112.
Erik M JorgensenHoward Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City, Utah 84112.
Michael AilionDepartment of Biochemistry, University of Washington, Seattle, Washington 98195 mailion@uw.edu.ORCID 0000-0002-8070-1362
University of Washington · USHoward Hughes Medical Institute · USUniversity of Utah · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANSR01NS034307 · NINDS · UNIVERSITY OF UTAH · PI JORGENSEN, ERIK M · 1995 to 2024
$5.8M
Regulation of Synaptic Transmission by GqR00MH082109 · NIMH · UNIVERSITY OF WASHINGTON · PI AILION, MICHAEL · 2011 to 2013
$726k
NIDDK NIH HHS P30 DK017047NIH HHS P40 OD010440NIMH NIH HHS R00 MH082109NINDS NIH HHS R01 NS034307
6 · The paper itself

Abstract

The heterotrimeric G protein G

Indexed as

AcetylcholineAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGTP-Binding Protein alpha Subunits, Gq-G11Ion ChannelsLocomotionMutationNerve Tissue ProteinsNeuronsSignal TransductionSynaptic TransmissionAcetylcholineCaenorhabditis elegans ProteinsGTP-Binding Protein alpha Subunits, Gq-G11Ion ChannelsNCA-2 protein, C elegansNerve Tissue Proteinsunc-77 protein, C elegansC. elegansG proteinGq signalingNCA/NALCN ion channelsRho small GTPase

Identifiers

PMID28325749
PMCPMC5419474
OpenAlexW2600247875

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.