ArticleCarbohydrate polymers2017
Structural and enzyme kinetic studies of retrograded starch: Inhibition of α-amylase and consequences for intestinal digestion of starch.
Article in Carbohydrate polymers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 143 citations in OpenAlex.
- Trial
- Effect of high-amyloseFood & function · 2022Trial
- Precision Nutrition Model Predicts Glucose Control of Overweight Females Following the Consumption of Potatoes High in Resistant Starch.Nutrients · 2022Trial
- Attenuation of glycaemic and insulin responses following tapioca resistant maltodextrin consumption in healthy subjects: a randomised cross-over controlled trial.Journal of nutritional science · 2020Trial
- A Comprehensive Review on Copper Oxide Nanoparticles: Physicochemical Parameters, Pharmacological Potential and Pathophysiological Effects.International journal of nanomedicine · 2026Review
- Identification of Selective α-Glucosidase Inhibitors via Virtual Screening with Machine Learning.Molecules (Basel, Switzerland) · 2025Article
- Microwave Treatment Improves Coarse Cereals' Texture and Cooking Quality.Food science & nutrition · 2025Article
- Efficacy of Endophytic BacteriumJournal of microbiology and biotechnology · 2025Article
- The Physicochemical and Rheological Properties of Green Banana Flour-Wheat Flour Bread Substitutions.Plants (Basel, Switzerland) · 2025Article
- Development of Whole-Grain Rice Lines Exhibiting Low and Intermediate Glycemic Index with Decreased Amylose Content.Foods (Basel, Switzerland) · 2024Article
- The Effect of Allulose on the Attenuation of Glucose Release from Rice in a Static In Vitro Digestion Model.Foods (Basel, Switzerland) · 2024Article
- Influence of Storage Temperature on Starch Retrogradation and Digestion of Chinese Steamed Bread.Foods (Basel, Switzerland) · 2024Article
- Comparison of structures and properties of gels formed by corn starch with fresh or driedCurrent research in food science · 2024Article
- Inhibitory Mechanism of Quercimeritrin as a Novel α-Glucosidase Selective Inhibitor.Foods (Basel, Switzerland) · 2023Article
- New Insights into the Latest Advancement in α-Amylase Inhibitors of Plant Origin with Anti-Diabetic Effects.Plants (Basel, Switzerland) · 2023Review
- Interfacial Catalysis during Amylolytic Degradation of Starch Granules: Current Understanding and Kinetic Approaches.Molecules (Basel, Switzerland) · 2023Review
- The Interplay of Dietary Fibers and Intestinal Microbiota Affects Type 2 Diabetes by Generating Short-Chain Fatty Acids.Foods (Basel, Switzerland) · 2023Review
- The Effects of Starch Molecular Fine Structure on Thermal and Digestion Properties of Rice Starch.Foods (Basel, Switzerland) · 2022Review
- Article
- Prebiotic Potential of Dietary Beans and Pulses and Their Resistant Starch for Aging-Associated Gut and Metabolic Health.Nutrients · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Retrograded starch is known to be resistant to digestion. We used enzyme kinetic experiments to examine how retrogradation of starch affects amylolysis catalysed by porcine pancreatic amylase. Parallel studies employing differential scanning calorimetry, infra red spectroscopy, X-ray diffraction and NMR spectroscopy were performed to monitor changes in supramolecular structure of gelatinised starch as it becomes retrograded. The total digestible starch and the catalytic efficiency of amylase were both decreased with increasing evidence of retrogradation. A purified sample of retrograded high amylose starch inhibited amylase directly. These new findings demonstrate that amylase binds to retrograded starch. Therefore consumption of retrograded starch may not only be beneficial to health through depletion of total digestible starch, and therefore the metabolisable energy, but may also slow the rate of intestinal digestion through direct inhibition of α-amylase. Such physiological effects have important implications for the prevention and management of type 2 diabetes and cardiovascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.