Evidence map›Paper›PMID 2832508›Full record

ArticleThe Journal of experimental medicine1988

Thymic lymphoma induction by the AKT8 murine retrovirus.

S P Staal, J W Hartley

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 99 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Phosphoinositides: Key modulators of energy metabolism.Biochimica et biophysica acta · 2015
    Review
  7. Review
  8. Article
  9. Review
  10. Myocardial AKT: the omnipresent nexus.Physiological reviews · 2011
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Specificity in the activation and control of transcription factor E2F-dependent apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2003
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

S P StaalJohns Hopkins Oncology Center, Baltimore, Maryland 21205.
J W Hartley

Funding

MOUSE LEUKEMIA VIRUS PROJECTN01AI022673 · NIAID · MICROBIOLOGICAL ASSOCIATES, INC. · PI PETERS, ROBERT L · 1985 to 1987
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NIAID NIH HHS N01-AI-22673
6 · The paper itself

Abstract

The directly transforming murine retrovirus, AKT8, was isolated from a spontaneous AKR thymoma and carries the cell-derived viral oncogene, akt. We have now shown that this virus produces thymic lymphomas after inoculation of susceptible mouse strains. The presence of the AKT8 genome in the DNA of the virus-induced tumors was demonstrated by Southern blotting using an akt-specific probe. These results establish the in vivo pathogenicity of the AKT8 virus and its akt oncogene, and imply a potential role for the cellular akt proto-oncogene in tumor development.

Indexed as

Genes, ViralOncogenesAnimalsDefective VirusesDNA, NeoplasmGammaretrovirusLymphomaMiceMice, Inbred AKRProvirusesThymus NeoplasmsDNA, Neoplasm

Identifiers

PMID2832508
PMCPMC2188879
OpenAlexW1997799275

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.