Evidence map›Paper›PMID 28324646›Full record

ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2017

From snapshots to movies: Understanding early tooth development in four dimensions.

Rebecca Kim, Jeremy B A Green, Ophir D Klein

Open access · bronzeAbstract readReview
In one paragraph

Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Tooth regeneration in animals. A systematic review.Medicina oral, patologia oral y cirugia bucal · 2025
    Pooled it
  2. Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026
    Review
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  6. Cellular mechanisms of reverse epithelial curvature in tissue morphogenesis.Frontiers in cell and developmental biology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Rebecca KimProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California San Francisco, San Francisco, California.ORCID 0000-0001-8309-9891
Jeremy B A GreenDepartment of Craniofacial Development & Stem Cell Biology, King's College London, London, United Kingdom.
Ophir D KleinProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California San Francisco, San Francisco, California.
University of California, San Francisco · USKing's College London · GB

Funding

Harnessing natural stem cell-based strategies for mammalian dental renewalR35DE026602 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2016 to 2023
$8.0M
The Role of Wnt Signaling in Early Tooth DevelopmentF30DE025160 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIM, REBECCA · 2015 to 2021
$323k
NIDCR NIH HHS F30 DE025160NIDCR NIH HHS R35 DE026602
6 · The paper itself

Abstract

The developing tooth offers a model for the study of ectodermal appendage organogenesis. The signaling networks that regulate tooth development have been intensively investigated, but how cell biological responses to signaling pathways regulate dental morphogenesis remains an open question. The increasing use of ex vivo imaging techniques has enabled live tracking of cell behaviors over time in high resolution. While recent studies using these techniques have improved our understanding of tooth morphogenesis, important gaps remain that require additional investigation. In addition, some discrepancies have arisen between recent studies, and resolving these will advance our knowledge of tooth development. Developmental Dynamics 246:442-450, 2016. © 2017 Wiley Periodicals, Inc.

Indexed as

OdontogenesisHumansImaging, Three-DimensionalMorphogenesisSignal TransductionToothcell behaviorepithelial dynamicsmolecular signalingmorphogenesistooth development

Identifiers

PMID28324646
PMCPMC5426979
OpenAlexW2745905098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.