ArticleMethods in molecular biology (Clifton, N.J.)2017
Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds.
Article in Methods in molecular biology (Clifton, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Variation and selection at predicted G-quadruplexes across the human pangenome.bioRxiv : the preprint server for biology · 2026Article
- QuaDB: A streamlined web tool for identifier-based rapid prediction of putative quadruplex sequences.Human genomics · 2026Article
- Potential for gene silencing by piwi-interacting RNA in three lepidopterans.Frontiers in insect science · 2026Article
- 8-Oxoguanine Disrupts G-Quadruplex DNA Stability and Modulates FANCJ AKKQ Peptide Binding.Molecules (Basel, Switzerland) · 2025Article
- Evolutionary dynamics of predicted G-quadruplexes in human and other great apes.Genome biology · 2025Article
- G-Quadruplexes in Tumor Immune Regulation: Molecular Mechanisms and Therapeutic Prospects in Gastrointestinal Cancers.Biomedicines · 2025Review
- Telomeric i-motifs and C-strands inhibit parallel G-quadruplex extension by telomerase.Nucleic acids research · 2023Article
- Alkylation of nucleobases by 2-chloro-NAR cancer · 2023Article
- Crystal structure of a three-tetrad, parallel, KActa crystallographica. Section F, Structural biology communications · 2023Article
- Review
- Maternal Serum Vitamin E Levels and its Association with Cord Blood Telomere Length and Mitochondrial DNA Copy Number in Preterm Premature Rupture of Membranes.Journal of obstetrics and gynaecology of India · 2023Article
- G-quadruplex occurrence and conservation: more than just a question of guanine-cytosine content.NAR genomics and bioinformatics · 2022Article
- Insights from Binding on Quadruplex Selective Carbazole Ligands.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Metal-Based G-Quadruplex Binders for Cancer Theranostics.Pharmaceuticals (Basel, Switzerland) · 2021Review
- The solution structures of higher-order human telomere G-quadruplex multimers.Nucleic acids research · 2021Article
- Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni.PLoS neglected tropical diseases · 2021Article
- PhenQE8, a Novel Ligand of the Human Telomeric Quadruplex.International journal of molecular sciences · 2021Article
- Subtelomeric Transcription and its Regulation.Journal of molecular biology · 2020Review
- Combining Alchemical Transformation with a Physical Pathway to Accelerate Absolute Binding Free Energy Calculations of Charged Ligands to Enclosed Binding Sites.Journal of chemical theory and computation · 2020Article
- Telomeres and Telomere Length: A General Overview.Cancers · 2020Review
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2 authors.
Funding
Abstract
G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures, and the human telomeric DNA G-quadruplexes are considered attractive targets for anticancer drugs. G-quadruplex-interactive compounds have been shown to inhibit telomerase access as well as telomere capping. Nuclear magnetic resonance (NMR) spectroscopy is a powerful method in determining the G-quadruplex structures under physiologically relevant conditions. We present the NMR and biophysical methodology used in our research group for the study of G-quadruplex structures in physiologically relevant solution and their interactions with small-molecule compounds.
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