ArticleThe journal of headache and pain2017
Anxiety and depression symptoms and migraine: a symptom-based approach research.
Article in The journal of headache and pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 6 of them syntheses that pooled it.
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Who cites it
134 citing papers in PubMed, 6 syntheses or guidelines pooled it, 293 citations in OpenAlex.
- Resting-state electroencephalography and magnetoencephalography in migraine-a systematic review and meta-analysis.The journal of headache and pain · 2024Pooled it
- Temporomandibular disorders in migraine and tension-type headache patients: a systematic review with meta-analysis.Journal of oral & facial pain and headache · 2024Pooled it
- Migraine in transient global amnesia: a meta-analysis of observational studies.Journal of neurology · 2022Pooled it
- The Prevalence of Migraine With Anxiety Among Genders.Frontiers in neurology · 2020Pooled it
- The Migraine-Anxiety Comorbidity Among Migraineurs: A Systematic Review.Frontiers in neurology · 2020Pooled it
- Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications.The journal of headache and pain · 2019Pooled it
- Cognitive Behavioral Therapy and Biofeedback for Chronic Headache: Effects on Pain Catastrophizing, Sleep Quality, and Disability.Journal of clinical psychology in medical settings · 2026Trial
- Smartphone-Based Muscle Relaxation for Migraine in the Emergency Department: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Headache psychiatry: A structured narrative review and integrative framework.PCN reports : psychiatry and clinical neurosciences · 2026Review
- Medial prefrontal cortex-targeted low-intensity focused ultrasound alleviates migraine-related allodynia and affective symptoms via modulating glutamate/GABA balance in mice.The journal of headache and pain · 2026Article
- Temporal Changes in Affective Symptoms, Headache Burden, and Quality of Life Following rTMS Treatment in Migraine: A Longitudinal Study.Healthcare (Basel, Switzerland) · 2026Article
- Sustained Efficacy of Eptinezumab in Participants with Migraine for Whom Prior Preventive Treatments Failed and Who Self-reported Psychiatric Comorbidities: Post Hoc Analysis of the Placebo-controlled DELIVER Trial.Neurology and therapy · 2026Article
- Sex-dependent cognitive and behavioral outcomes induced by repetitive cortical spreading depression in mice.The journal of headache and pain · 2026Article
- Elucidating biopsychosocial mechanisms in migraine: an integrative analytics approach combining genetics, neuroimaging, and machine learning.The journal of headache and pain · 2026Article
- Persistent headache after aneurysmal subarachnoid hemorrhage: Prevalence, characteristics, and migraine history as a prognostic factor.Headache · 2026Article
- A neurological perspective on Tarsila do Amaral's "Abaporu": migraine aura inspiring art?Arquivos de neuro-psiquiatria · 2026Review
- Optimizing Identification and Management of Depression in Neurological Diseases: A Narrative Review and Expert Perspective.Neuropsychiatric disease and treatment · 2026Article
- Electroacupuncture for Menstrual-Related Migraine: Protocol for a Multicenter Single-Blinded Randomized Controlled Trial.Pain research & management · 2026Article
- A potential neuroimaging biomarker for depression in migraine patients: imbalance in excitation and inhibition in the medial superior frontal cortex.Journal of psychiatry & neuroscience : JPN · 2026Article
- Causal influences of migraine on neuropsychiatric disorders: A 2-sample Mendelian randomization study.Medicine · 2025Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnxiety and mood disorders have been shown to be the most relevant psychiatric comorbidities associated with migraine, influencing its clinical course, treatment response, and clinical outcomes. Limited information is available on how specific anxiety and depression symptoms are related to migraine. Symptoms-based approach, a current trend in mental health research, may improve our understanding in migraine comorbidity. The purpose of this study was to analyze how anxiety and depression aspects are related to migraine through a symptom-based approach.
methodsWe studied 782 patients from the general population who completed a self-administered questionnaire assessing demographics, headache features, anxiety and depression symptoms. A binary logistic regression analyses were conducted to test the association between all four ratings in GAD-7 (anxiety) and PHQ-9 (depression) scales subitems as covariates, and migraine vs no headache as the outcome.
resultsThe leading Odd Ratios (OR) observed in individuals with migraine relative to those without migraine were anxiety related, "Not being able to stop or control worrying" on a daily basis [OR (CI 95%)] 49.2 (13.6-178.2), "trouble relaxing" 25.7 (7.1-92.6), "Feeling nervous, anxious or on edge" on a daily basis 25.4 (6.9-93.8), and "worrying too much about different things" 24.4 (7.7-77.6). Although the hallmark symptoms of depression are emotional (hopelessness and sadness), the highest scores found were physical: apetite, fatigue, and poor sleep. Irritability had a significant increase in migraine risk [OR 3.8 (1.9-7.8) if experienced some days, 7.5 (2.7-20.7) more than half the days, and 22.0 (5.7-84.9) when experienced nearly every day].
conclusionsAnxiety was more robustly associated with increase in migraine risk than depression. Lack of ability to properly control worrying and to relax are the most prominent issues in migraine psychiatric comorbidity. Physical symptoms in depression are more linked to migraine than emotional symptoms. A symptom-based approach helps clarifying migraine comorbidity and should be replicated in other studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.