Recurrent bowel-blood translocations of Escherichia coli with the unique virulence characteristics over three-year period in the patient with acute myeloid leukaemia - case report.

Beata Krawczyk, Anna Śledzińska, Agnieszka Piekarska, Andrzej Hellmann, Józef Kur

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In one paragraph

Article in Journal of applied genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed

–field-weighted citation impact

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3 citing papers in PubMed.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Beata KrawczykDepartment of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland.

Anna ŚledzińskaDepartment of Therapy Monitoring and Pharmacogenetics, Medical University of Gdansk, Gdańsk, Poland.

Agnieszka PiekarskaDepartment of Hematology and Transplantology, Medical University of Gdańsk, University Clinical Center, Dębinki 7, 80-952, Gdańsk, Poland. babajaga@gumed.edu.pl.ORCID http://orcid.org/0000-0002-1593-8005

Andrzej HellmannDepartment of Hematology and Transplantology, Medical University of Gdańsk, University Clinical Center, Dębinki 7, 80-952, Gdańsk, Poland.

Józef KurDepartment of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with haematological malignancies, the bowel remains the main source of Escherichia coli bloodstream infections. We present the clinical example of recurrent bowel-blood translocations of E. coli with the unique virulence characteristics in a 55-year-old male with the diagnosis of acute myeloid leukaemia. The virulent factors profile of examined strains confirmed that the co-existence of genes papC, sfa, usp and cnf1, encoding virulence factors, predisposes E. coli to translocation from the gastrointestinal tract to the vascular bed. The close cooperation between haematologists and microbiologists is essential to improve the outcome of patients colonised with highly pathogenic strains.

Indexed as

Bacterial TranslocationEscherichia coliEscherichia coli InfectionsGenes, BacterialHumansIntestinesLeukemia, Myeloid, AcuteMaleMiddle AgedVirulenceVirulence FactorsVirulence FactorsBacteraemiaBowel translocationEscherichia coliLeukaemiaVirulence factors

Identifiers

PMID28324282

DOI10.1007/s13353-017-0393-6

PMCPMC5509818

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