SynthesisNeurocritical care2017
Stroke and Intracranial Hemorrhage in HeartMate II and HeartWare Left Ventricular Assist Devices: A Systematic Review.
Synthesis in Neurocritical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update.Stroke and vascular neurology · 2023Guideline
- Preoperative brain volume loss is associated with postoperative delirium in advanced heart failure patients supported by left ventricular assist device.Scientific reports · 2025Article
- Management of LVAD in Cerebral Salt-Wasting Syndrome.Case reports in critical care · 2025Article
- A comparison of quality-adjusted life years in older adults after heart transplantation versus long-term mechanical support: Findings from the SUSTAIN-IT study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- Review
- Outcomes of heart transplant recipients with prior left ventricular assist device associated stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023Article
- Neurologic Complications in Patients With Left Ventricular Assist Devices.The Canadian journal of cardiology · 2023Review
- Cerebral Microvascular Injury in Patients with Left Ventricular Assist Device: a Neuropathological Study.Translational stroke research · 2022Article
- Stroke epidemiology and outcomes in the modern era of left ventricular assist devices.Heart failure reviews · 2022Review
- A data mining-based cross-industry process for predicting major bleeding in mechanical circulatory support.European heart journal. Digital health · 2021Article
- Prothrombin Complex Concentrate for Emergent Reversal of Intracranial Hemorrhage in Patients with Ventricular Assist Devices.Neurocritical care · 2021Article
- The Use of Factor Eight Inhibitor Bypass Activity (FEIBA) for the Treatment of Perioperative Hemorrhage in Left Ventricular Assist Device Implantation.Journal of cardiothoracic and vascular anesthesia · 2021Article
- Neurocritical Care of Mechanical Circulatory Support Devices.Current neurology and neuroscience reports · 2021Review
- Factor Xa inhibitors in patients with continuous-flow left ventricular assist devices.General thoracic and cardiovascular surgery · 2020Article
- The Dilemma of Resuming Antithrombotic Therapy After Intracranial Hemorrhage in Patients With Left Ventricular Assist Devices.Neurocritical care · 2020Article
- Assessing Cerebrovascular Hemodynamics Using Transcranial Doppler in Patients with Mechanical Circulatory Support Devices.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- Factors defining occurrence of ischemic and hemorrhagic strokes during continuous flow left ventricular assist device support.General thoracic and cardiovascular surgery · 2020Article
- Bleeding in critical care associated with left ventricular assist devices: pathophysiology, symptoms, and management.Hematology. American Society of Hematology. Education Program · 2019Article
- Innovative Modeling Techniques and 3D Printing in Patients with Left Ventricular Assist Devices: A Bridge from Bench to Clinical Practice.Journal of clinical medicine · 2019Review
- Neurological Complications of Cardiological Interventions.Current neurology and neuroscience reports · 2019Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIschemic stroke and intracranial hemorrhage (ICH) following left ventricular assist device (LVAD) placement are major causes of morbidity. The incidence and mortality associated with these events stratified by device type have not been systematically explored.
methodsA systematic review of PubMed was conducted from January 2007 through June 2016 for all English-language articles involving HeartMate II (HMII) and HeartWare LVAD patients. Ischemic stroke and/or ICH incidence (events per patient-year) and associated mortality rates were abstracted for each device type.
resultsOf 735 articles reviewed, 48 (11,310 patients) met inclusion criteria (33 HMII, six HeartWare, eight both devices, and one unspecified). The median duration of device support was 112 days (total 13,723 patient-years). Overall, ischemic stroke or ICH occurred in 9.8% (1110 persons and 0.08 events per patient year [EPPY]). Ischemic stroke occurred in a median of 6.0% or 0.06 EPPY (range 0-16% or 0-0.21 EPPY) of HMII patients versus 7.5% or 0.09 EPPY (range 4-17.1% or 0.01-0.94 EPPY) of HeartWare patients. ICH occurred in a median of 3.0% or 0.04 EPPY (range 0-13.5% or 0-0.13 EPPY) of HMII and 8.0% or 0.08 EPPY (range 3-23% or 0.01-0.56 EPPY) of HeartWare patients. The median mortality rate for LVAD-associated ischemic stroke was 31% (HMII: 33%, [range 2.4-75%] and HeartWare: 11.5% [range 3.9-40%]), and the median mortality rate following ICH was 71% (HMII: 75%, [range 3.9-100%] and HeartWare: 44%, [range 3.1-88%]).
conclusionsIschemic stroke and ICH are common after LVAD placement, but heterogeneous event rates are reported in the literature. Given the high associated mortality, further prospective study is warranted.
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