ReviewJournal of neural transmission (Vienna, Austria : 1996)2018
Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 68 citations in OpenAlex.
- The parafascicular thalamus steers attention to facilitate learning.bioRxiv : the preprint server for biology · 2026Article
- From lobotomy to connectomics: a critical review of contemporary psychosurgery.Frontiers in psychiatry · 2026Review
- Disrupted intrathalamic and thalamocortical structural covariance networks in posttraumatic stress disorder.Network neuroscience (Cambridge, Mass.) · 2026Article
- Dorsomedial striatum monitors unreliability of current action policy and probes alternative one via the indirect pathway.Science advances · 2025Article
- Cholinergic modulation enables scalable action selection learning in a computational model of the striatum.Scientific reports · 2025Article
- Extrinsic and intrinsic control of striatal cholinergic interneuron activity.Frontiers in molecular neuroscience · 2025Review
- A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Aggregation ofBiomedicines · 2024Article
- The Basal Ganglia Downstream Control of Action - An Evolutionarily Conserved Strategy.Current neuropharmacology · 2024Review
- Pedunculopontine Chx10Nature neuroscience · 2023Article
- Dynamic prospect theory: Two core decision theories coexist in the gambling behavior of monkeys and humans.Science advances · 2023Article
- The rostral intralaminar nuclear complex of the thalamus supports striatally mediated action reinforcement.eLife · 2023Article
- Connectivity of the corticostriatal and thalamostriatal systems in normal and parkinsonian states: An update.Neurobiology of disease · 2022Review
- Article
- Dissociable roles for the striatal cholinergic system in different flexibility contexts.IBRO neuroscience reports · 2022Article
- Distinct roles for motor cortical and thalamic inputs to striatum during motor skill learning and execution.Science advances · 2022Article
- Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility.The Journal of clinical investigation · 2022Article
- Dignity neuroscience: universal rights are rooted in human brain science.Annals of the New York Academy of Sciences · 2021Review
- Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress.Endocrinology · 2021Review
- Neural Representation of Costs and Rewards in Decision Making.Brain sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
The thalamus provides a massive input to the striatum, but despite accumulating evidence, the functions of this system remain unclear. It is known, however, that the centromedian (CM) and parafascicular (Pf) nuclei of the thalamus can strongly influence particular striatal neuron subtypes, notably including the cholinergic interneurons of the striatum (CINs), key regulators of striatal function. Here, we highlight the thalamostriatal system through the CM-Pf to striatal CINs. We consider how, by virtue of the direct synaptic connections of the CM and PF, their neural activity contributes to the activity of CINs and striatal projection neurons (SPNs). CM-Pf neurons are strongly activated at sudden changes in behavioral context, such as switches in action-outcome contingency or sequence of behavioral requirements, suggesting that their activity may represent change of context operationalized as associability. Striatal CINs, on the other hand, acquire and loose responses to external events associated with particular contexts. In light of this physiological evidence, we propose a hypothesis of the CM-Pf-CINs system, suggesting that it augments associative learning by generating an associability signal and promotes reinforcement learning guided by reward prediction error signals from dopamine-containing neurons. We discuss neuronal circuit and synaptic organizations based on in vivo/in vitro studies that we suppose to underlie our hypothesis. Possible implications of CM-Pf-CINs dysfunction (or degeneration) in brain diseases are also discussed by focusing on Parkinson's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.