Evidence map›Paper›PMID 28324168›Full record

Trial reportEuropean journal of applied physiology2017

The effect of eccentric exercise with blood flow restriction on neuromuscular activation, microvascular oxygenation, and the repeated bout effect.

Jakob D Lauver, Trent E Cayot, Timothy Rotarius, Barry W Scheuermann

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04682392 (The Effects of Bone Health on Landing Mechanics on Patients Post ACL Reconstruction.), which is not on this map. Cited by 25 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04682392 naterminatednot on this mapstarted 2021, after this paper: background citation

The Effects of Bone Health on Landing Mechanics on Patients Post ACL Reconstruction.

TypeinterventionalSponsorCandice Dunkin, MS, LAT, ATCRan2021 to 2025Enrolled19ConditionsACL TearArmsDelfi's PTS Personalized Tourniquet System for Blood Flow Restriction Group, Standard ACL rehab
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jakob D LauverDepartment of Exercise and Rehabilitative Sciences, University of Toledo, 2801 West Bancroft Street, Toledo, OH, 43606, USA. jlauver@adrian.edu.
Trent E CayotDepartment of Exercise and Rehabilitative Sciences, University of Toledo, 2801 West Bancroft Street, Toledo, OH, 43606, USA.
Timothy RotariusDepartment of Exercise and Rehabilitative Sciences, University of Toledo, 2801 West Bancroft Street, Toledo, OH, 43606, USA.
Barry W ScheuermannDepartment of Exercise and Rehabilitative Sciences, University of Toledo, 2801 West Bancroft Street, Toledo, OH, 43606, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the effect of low-intensity eccentric contractions with and without blood flow restriction (BFR) on microvascular oxygenation, neuromuscular activation, and the repeated bout effect (RBE).

methodsParticipants were randomly assigned to either low-intensity (LI), low-intensity with BFR (LI-BFR), or a control (CON) group. Participants in LI and LI-BFR performed a preconditioning bout of low-intensity eccentric exercise prior to about of maximal eccentric exercise. Participants reported 24, 48, 72, and 96 h later to assess muscle damage and function. Surface electromyography (sEMG) and near-infrared spectroscopy (NIRS) were used to measure neuromuscular activation and microvascular deoxygenation (deoxy-[Hb + Mb]) and [total hemoglobin] ([THC]) during the preconditioning bout, respectively.

resultsDuring set-2, LI-BFR resulted in greater activation of the VM-RMS (47.7 ± 11.5% MVIC) compared to LI (67.0 ± 20.0% MVIC), as well as during set-3 (p < 0.05). LI-BFR resulted in a greater change in deoxy-[Hb + Mb] compared to LI during set-2 (LI-BFR 13.1 ± 5.2 µM, LI 6.7 ± 7.9 µM), set-3 (LI-BFR 14.6 ± 6 µM, LI 6.9 ± 7.4 µM), and set-4 (p < 0.05). [THC] was higher during LI-BFR compared to LI (p < 0.05). All groups showed a decrease in MVIC torque immediately after maximal exercise (LI 74.2 ± 14.1%, LI-BFR 75 ± 5.1%, CON 53 ± 18.6%). At 24, 48, 72, and 96 h post maximal eccentric exercise, LI and LI-BFR force deficit was not different from baseline.

conclusionThis study suggests that the neuromuscular and deoxygenation (i.e., metabolic stress) responses were considerably different between LI and LI-BFR groups; however, these differences did not lead to improvements in the RBE inferred by performing LI and LI-BFR.

Indexed as

ExerciseOxygen ConsumptionAdultHumansIschemic PreconditioningMaleMicrovesselsMuscle ContractionMuscle, SkeletalMyalgiaRegional Blood FlowBlood flow restrictionNear-infrared spectroscopyRepeated bout effect

Identifiers

PMID28324168

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.