ArticleEndocrinology2017
Hippocampal Aromatization Modulates Spatial Memory and Characteristics of the Synaptic Membrane in the Male Zebra Finch.
Article in Endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- What do zebra finches learn besides singing? Systematic mapping of the literature and presentation of an efficient associative learning test.Animal cognition · 2023Pooled it
- Letrozole delays acquisition of water maze task in female BALB/c mice: Possible involvement of anxiety.Hormones and behavior · 2024Article
- Differences in vocal brain areas and astrocytes between the house wren and the rufous-tailed hummingbird.Frontiers in neuroanatomy · 2024Article
- Spatial and temporal specificity of neuroestradiol provision in the songbird.Journal of neuroendocrinology · 2023Review
- Estradiol decreases the excitability of RA projection neurons in adult male zebra finches.Frontiers in cellular neuroscience · 2023Article
- Brain-Generated 17β-Estradiol Modulates Long-Term Synaptic Plasticity in the Primary Auditory Cortex of Adult Male Rats.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Brain-derived estrogen and neural function.Neuroscience and biobehavioral reviews · 2022Review
- Neuron-Derived Estrogen-A Key Neuromodulator in Synaptic Function and Memory.International journal of molecular sciences · 2021Review
- De Novo Synthesized Estradiol: A Role in Modulating the Cerebellar Function.International journal of molecular sciences · 2020Review
- Neuroestrogen synthesis modifies neural representations of learned song without altering vocal imitation in developing songbirds.Scientific reports · 2020Article
- Estrogen as a Neuroprotectant in Both Sexes: Stories From the Bird Brain.Frontiers in neurology · 2020Review
- G Protein-Coupled Estrogen Receptor Immunoreactivity Fluctuates During the Estrous Cycle and Show Sex Differences in the Amygdala and Dorsal Hippocampus.Frontiers in endocrinology · 2020Article
- Rapid Estrogenic and Androgenic Neurosteroids Effects in the Induction of Long-Term Synaptic Changes: Implication for Early Memory Formation.Frontiers in neuroscience · 2020Review
- Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition.Hormones and behavior · 2019Article
- Non-reproductive Functions of Aromatase in the Central Nervous System Under Physiological and Pathological Conditions.Cellular and molecular neurobiology · 2019Review
- Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Adverse Effects of Aromatase Inhibition on the Brain and Behavior in a Nonhuman Primate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Mechanisms underlying the rapid effects of estradiol and progesterone on hippocampal memory consolidation in female rodents.Hormones and behavior · 2018Review
- Neuroestrogens rapidly shape auditory circuits to support communication learning and perception: Evidence from songbirds.Hormones and behavior · 2018Review
- Estrogenic regulation of memory consolidation: A look beyond the hippocampus, ovaries, and females.Physiology & behavior · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The estrogen-synthesizing enzyme aromatase is abundant at the synapse in the zebra finch hippocampus (HP), and its inhibition impairs spatial memory function. To more fully test the role of local estradiol (E2) synthesis in memory, the HP of adult male zebra finches was exposed to either control pellets or those containing the aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD), ATD and E2, ATD and the G protein-coupled estrogen receptor (GPER) agonist G1, or the antagonist G15 alone. Birds were tested for spatial memory acquisition and performance, and HP levels of the postsynaptic protein PSD95 were measured. ATD-treated birds took longer to reach criterion than control birds, whereas acquisition in ATD+E2 and ATD+G1 birds was indistinguishable from control and ATD treatments. Interestingly, all G15 birds failed to acquire the task. Following a retention interval, ATD birds took the longest to reach the (formerly) baited cup and made the most mistakes. ATD+E2 animals displayed the lowest retention latencies and made fewer mistakes than ATD-treated birds, and ATD+G1 birds did not significantly differ from controls in retention latencies. The amount of PSD95 in the HP was lowest in ATD-treated animals compared with birds with silicone-only-implanted craniotomies, ATD+E2, and ATD+G1 birds, who did not differ in this expression. Thus, spatial memory acquisition and performance appear aromatase and E2 dependent, an effect more reliably revealed after consolidation and/or recall compared to acquisition. E2 may exert this effect via GPERs, resulting in an increase in PSD95 levels that may modify receptor activity or intracellular signaling pathways to increase synaptic strength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.