Observational studyThe Journal of clinical endocrinology and metabolism2017
Thyroid Status and Mortality in a Prospective Hemodialysis Cohort.
Observational study in The Journal of clinical endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients
A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients
Studying Thyroid Function of Haemodialysis Patients in Upper Egypt (Two Centers Study).
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Prevalence and incidence of hypothyroidism and hyperthyroidism in patients with chronic kidney disease on dialysis: a systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Trial
- Thyroid Stimulating Hormone Levels and Risk of Hospital-Acquired Acute Kidney Injury: A Nationwide Cohort Study.Kidney medicine · 2026Article
- Hemodialysis Tends to Improve Thyroid Function by Restoring Hormone Levels in ESRD Patients Compared to Non-Dialysis Kidney Disease Patients: A Case-Control Study.Diseases (Basel, Switzerland) · 2026Article
- Kidney diseases and the thyroid: interactions and consequences.Nature reviews. Endocrinology · 2026Review
- Thyroid Function and All-cause Mortality in the Context of Multimorbidity: Results From 2 Population-based Studies.The Journal of clinical endocrinology and metabolism · 2026Article
- Understanding the Drivers of Hypothyroidism in Patients Undergoing Chronic Hemodialysis.Diagnostics (Basel, Switzerland) · 2026Article
- Sleep Patterns, Symptoms, and Mortality in Hemodialysis: A Prospective Cohort Study.Kidney medicine · 2025Article
- Assessment of Renal Function in Patients with Chronic Kidney Disease with and without Hypothyroidism.Ethiopian journal of health sciences · 2025Article
- Phosphate Binder Impairs Levothyroxine Absorption in a Hypothyroid Patient With End-Stage Renal Disease.Cureus · 2024Article
- Impact of Thyroid Status on Incident Kidney Dysfunction and Chronic Kidney Disease Progression in a Nationally Representative Cohort.Mayo Clinic proceedings · 2024Article
- Development and Validation of a Prediction Model for Incident Hypothyroidism in a National Chronic Kidney Disease Cohort.The Journal of clinical endocrinology and metabolism · 2023Article
- Choosing the right chronic medication for hemodialysis patients. A short ABC for the dialysis nephrologist.Journal of nephrology · 2023Review
- Clinicopathological features and prognosis of idiopathic membranous nephropathy with thyroid dysfunction.Frontiers in endocrinology · 2023Article
- Kidney disease and thyroid dysfunction: the chicken or egg problem.Pediatric nephrology (Berlin, Germany) · 2022Review
- Elevated serum thyrotropin levels and endothelial dysfunction in a prospective hemodialysis cohort.Hemodialysis international. International Symposium on Home Hemodialysis · 2022Article
- Serum Thyrotropin Elevation and Coronary Artery Calcification in Hemodialysis Patients.Cardiorenal medicine · 2022Article
- Dietary Potassium Intake and Mortality in a Prospective Hemodialysis Cohort.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2021Article
- The Interplay Between Thyroid Dysfunction and Kidney Disease.Seminars in nephrology · 2021Review
- A Pilot Trial on the Effect of Levothyroxine on Proteinuria in Patients With Advanced CKD.Kidney international reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
Context and Objective: Compared with the general population, hemodialysis patients have a substantially higher risk of hypothyroidism, as defined by an elevated serum thyrotropin (TSH) level, and cardiovascular mortality. Whereas an elevated TSH is associated with cardiovascular disease and death in the general population, associations among dialysis patients have been inconsistent. Design, Setting, Participants, and Main Outcome: We examined 541 hemodialysis patients from 17 southern California dialysis centers in the prospective Hypothyroidism, Cardiovascular Health, and Survival study who underwent protocolized measurement of repeated serum TSH levels every 6 months from 2013 to 2015. Associations between TSH tertiles (<1.28, 1.28 to <2.14, and 2.14 to 86.7 mIU/L) and mortality were estimated using time-dependent Cox models with four adjustment levels. In sensitivity analyses, we excluded patients receiving thyroid hormone supplementation. Results: Compared with the lowest TSH tertile, the highest TSH tertile was associated with a 2.2- to 2.5-fold higher mortality risk in unadjusted, case-mix, expanded case-mix+laboratory, and expanded case-mix+laboratory+medication models [hazard ratios (95% confidence interval), 2.54 (1.32 to 4.89), 2.53 (1.30 to 4.93), 2.19 (1.11 to 4.32), and 2.28 (1.45 to 3.58), respectively]. We observed a consistent trend between higher TSH tertiles and numerically higher mortality risk across all models. Similar findings were observed in analyses excluding patients receiving thyroid hormone supplementation. Conclusion: In time-dependent analyses, TSH levels in the high-normal to high range were independently associated with higher death risk in hemodialysis patients. Further studies are indicated to determine whether normalization of TSH levels with thyroid hormone supplementation improves survival in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.