ArticleThe Journal of clinical endocrinology and metabolism2017
Obesity Modulates Inflammation and Lipid Metabolism Oocyte Gene Expression: A Single-Cell Transcriptome Perspective.
Article in The Journal of clinical endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic review of mRNA expression in human oocytes: understanding the molecular mechanisms underlying oocyte competence.Journal of assisted reproduction and genetics · 2023Pooled it
- Periconceptional biomarkers for maternal obesity: a systematic review.Reviews in endocrine & metabolic disorders · 2023Pooled it
- A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View.International journal of molecular sciences · 2022Pooled it
- Distinct From the Adult Paradigm: Re-Evaluate the Pathophysiological and Therapeutic Framework in Children and Adolescent Hyperlipidaemia.Current obesity reports · 2026Review
- A review of the association between abnormal body mass index and oocyte quality.Journal of ovarian research · 2026Review
- Postweaning diet affects offspring metabolic outcomes more than maternal diet in male and female mice.Physiological reports · 2026Article
- Maternal obesity disrupts epigenetic reprogramming via peroxisomal-dependent phospholipid-methyl uncoupling during zygotic genome activation.Nature communications · 2026Article
- Obesity Affects IVF Outcomes and Mevalonic Acid Rescues the Side Effects of Statins on Follicle Growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- New aspect on the regulation of in vitro oocyte maturation: role of the obesity, neuropeptides and adipokines.Journal of assisted reproduction and genetics · 2025Review
- Immune imbalance in the pre-ovulatory follicular microenvironment of overweight and obese women during IVF.Journal of ovarian research · 2025Article
- The dual burden of obesity: decoding metabolism and female reproductive endocrinology.Frontiers in physiology · 2025Review
- Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice.Biology direct · 2024Article
- Leptin signalling regulates transcriptional differences in granulosa cells from genetically obese mice but not the activation of NLRP3 inflammasome.Scientific reports · 2024Article
- Cellular atlases of ovarian microenvironment alterations by diet and genetically-induced obesity.Science China. Life sciences · 2024Article
- Molecular nutrition in life course perspective: Pinpointing metabolic pathways to target during periconception.Maternal & child nutrition · 2024Article
- Changes in Inflammatory Cytokines, Vascular Markers, Cell Cycle Regulators, and Gonadotropin Receptors in Granulosa Cells of COVID-19 Infected Women.Galen medical journal · 2024Article
- Serum uric acid did not affect embryonic and pregnancy outcomes in women without PCOS during IVF procedures.Frontiers in endocrinology · 2024Article
- Cuban Policosanol (RaydelMolecules (Basel, Switzerland) · 2023Article
- Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course.Nature reviews. Cardiology · 2023Review
- Effects of obesity on the serum BMP15, GDF9, and kisspeptin concentrations in women of reproductive age.Journal of medical biochemistry · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Context: It is hypothesized that obesity adversely affects the ovarian environment, which can disrupt oocyte maturation and embryonic development. Objective: This study aimed to compare oocyte gene expression profiles and follicular fluid (FF) content from overweight/obese (OW) women and normal-weight (NW) women who were undergoing fertility treatments. Design: Using single-cell transcriptomic analyses, we investigated oocyte gene expression using RNA sequencing. Patients or Other Participants: Eleven OW women and 13 NW women undergoing fertility treatments were enrolled. Main Outcome Measures: Oocyte messenger RNA profiles as well as serum and FF hormone and lipid levels were assessed. Results: OW women had significantly higher body mass index, body fat percentage, and serum homeostatic model assessment-insulin resistance index compared with NW women (P < 0.01). Serum leptin and C-reactive protein (CRP) levels as well as FF leptin, CRP, and triglyceride levels were increased (P < 0.05) in OW compared with NW women. Oocytes from OW women had increased expression of proinflammatory (CXCL2; P = 0.071) and oxidative stress-related (DUSP1; P = 0.051) genes but had decreased expression of GAS7 (fat metabolism; P = 0.065), TXNIP (oxidative stress; P = 0.055), and transcription factors ID3 (P = 0.075) and TWIST1 (P = 0.099) compared with NW women. Conclusions: These findings provide evidence for the significant influence of body composition on oocyte transcript abundance in women undergoing hormonal induction to retrieve oocytes. They further identify the potential for maternal diet to influence oocyte gene expression. The preconception period is, therefore, an important window of opportunity to consider for lifestyle interventions.
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Registered trials
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