ArticlePloS one2017
The clinical features, outcomes and genetic characteristics of hypertrophic cardiomyopathy patients with severe right ventricular hypertrophy.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Prevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy.Scientific reports · 2020Trial
- Unusual hypertrophic cardiomyopathy with severe right ventricular outflow tract obstruction and two septal aneurysms: a case report.BMC cardiovascular disorders · 2026Article
- Integrative transcriptomic analysis revealed the roles and prognostic value of ion channels in hypertrophic cardiomyopathy.Frontiers in pharmacology · 2026Article
- Significance of the Monitoring Right Ventricular Echocardiographic Parameters in Patients with Hypertrophic Cardiomyopathy Undergoing Alcohol Septal Ablation-A Single-Center Experience.Diagnostics (Basel, Switzerland) · 2025Article
- Favorable cardiac remodeling in response to treatment in obstructive hypertrophic cardiomyopathy: a current appraisal.Future cardiology · 2025Review
- Extreme Right Ventricular Pseudohypertrophy Due to Myocardial Edema.International journal of heart failure · 2025Article
- Unveiling the Spectrum of Minor Genes in Cardiomyopathies: A Narrative Review.International journal of molecular sciences · 2024Review
- Mavacamten in Right Ventricular Outflow Tract Obstruction.JACC. Case reports · 2024Article
- What is this image? 2022 Image 4 result: Massive right ventricular hypertrophy detected by Tc-99m sestamibi SPECT MPI study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- A case of hypertrophic cardiomyopathy with right ventricular outflow tract and left midventricular obstruction.Journal of cardiology cases · 2022Article
- Isolated extreme right ventricular hypertrophy: A case report.Journal of cardiology cases · 2022Article
- The role of the M-band myomesin proteins in muscle integrity and cardiac disease.Journal of biomedical science · 2022Review
- Arrhythmic risk stratification by cardiac magnetic resonance tissue characterization: disclosing the arrhythmic substrate within the heart muscle.Heart failure reviews · 2022Review
- Right ventricular phenotype, function, and failure: a journey from evolution to clinics.Heart failure reviews · 2021Review
- Severe right ventricular hypertrophy in hypertrophic cardiomyopathy: Serious symptoms, complex surgical procedures, and poor prognosis in Fuwai Hospital.Anatolian journal of cardiology · 2021Article
- Effects of Captopril and Losartan on Cardiac Stereology in Rats with Renovascular Hypertension.Iranian journal of medical sciences · 2021Article
- Role of Cardiac Magnetic Resonance in Detecting Biventricular Apical Hypertrophic Cardiomyopathy.Case reports in cardiology · 2021Article
- Possible Azithromycin-Induced Life-Threatening Arrhythmia Requiring Extracorporeal Membrane Oxygenation Support: A Case Report.The American journal of case reports · 2020Article
- Soluble ST2, Galectin-3 and clinical prognosis of patients with hypertrophic cardiomyopathy undergoing ventricular septal myectomy: a correlation analysis.Cardiovascular diagnosis and therapy · 2020Article
- Diastolic Paradoxic Jet Flow of the Right Ventricle in Hypertrophic Cardiomyopathy.Journal of medical cases · 2020Article
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSevere right ventricular hypertrophy (SRVH) is a rare phenotype in hypertrophic cardiomyopathy (HCM) for which limited information is available. This study was undertaken to investigate the clinical, prognostic and genetic characteristics of HCM patients with SRVH.
methodsHCM with SRVH was defined as HCM with a maximum right ventricular wall thickness ≥10 mm. Whole-genome sequencing (WGS) was performed in HCM patients with SRVH. Multivariate Cox proportional hazards regression models were used to identify risk factors for cardiac death and events in HCM with SRVH. Patients with apical hypertrophic cardiomyopathy (ApHCM) were selected as a comparison group. The clinical features and outcomes of 34 HCM patients with SRVH and 273 ApHCM patients were compared.
resultsCompared with the ApHCM group, the HCM with SRVH group included younger patients and a higher proportion of female patients and also displayed higher cardiovascular morbidity and mortality. The multivariate Cox proportional hazards regression models identified 2 independent predictors of cardiovascular death in HCM patients with SRVH, a New York Heart Association class ≥III (hazard ratio [HR] = 8.7, 95% confidence interval (CI): 1.43-52.87, p = 0.019) and an age at the time of HCM diagnosis ≤18 (HR = 5.5, 95% CI: 1.24-28.36, p = 0.026). Among the 11 HCM patients with SRVH who underwent WGS, 10 (90.9%) were identified as carriers of at least one specific sarcomere gene mutation. MYH7 and TTN mutations were the most common sarcomere mutations noted in this study. Two or more HCM-related gene mutations were observed in 9 (82%) patients, and mutations in either other cardiomyopathy-related genes or ion-channel disease-related genes were found in 8 (73%) patients.
conclusionsHCM patients with SRVH were characterized by poor clinical outcomes and the presentation of multiple gene mutations.
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