ReviewCurrent opinion in anaesthesiology2017
Codeine and opioid metabolism: implications and alternatives for pediatric pain management.
Review in Current opinion in anaesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 69 citations in OpenAlex.
- Oxycodone preemptive analgesia after endoscopic plasma total adenotonsillectomy in children: A randomized controlled trial.Medicine · 2020Trial
- Personalized Perioperative Opioid Strategies in Children: Focus on Methadone, Pharmacogenomics and Prevention of Persistent Postoperative Opioid Use.Children (Basel, Switzerland) · 2025Review
- Spinal anesthesia with caudal catheter in pediatric urologic surgery: an alternative to general anesthesia.Frontiers in pediatrics · 2025Article
- The Cytotoxic Effects of Nyaope, a Heroin-based Street Drug, inIBRO neuroscience reports · 2024Article
- Health Canada advisory impacts on the prevalence of oral codeine use in the Pediatric Canadian population: comparative study across provinces.Scientific reports · 2024Article
- Article
- Effects of pharmacogenetic profiles on pediatric pain relief and adverse events with ibuprofen and oxycodone.Pain reports · 2023Article
- A software tool to adjust codeine dose based on CYP2D6 gene-pair polymorphisms and drug-drug interactions.The pharmacogenomics journal · 2023Review
- Outpatient Opioid Dispensing Patterns for SC Medicaid Children 1-36 Months Old.Maternal and child health journal · 2023Article
- Association ofAnnals of translational medicine · 2022Article
- Does photobiomodulation therapy improve the postoperative outcomes of tonsillectomy? A systematic review and meta-analysis.Journal of lasers in medical sciences · 2022Review
- Analgesic Effects and Safety of Dexmedetomidine Added to Nalbuphine or Sufentanil Patient-Controlled Intravenous Analgesia for Children After Tonsillectomy Adenoidectomy.Frontiers in pharmacology · 2022Article
- [Pediatric pain treatment and prevention for hospitalized children].Schmerz (Berlin, Germany) · 2021Review
- Expert review and recommendations for the management of acute, chronic, and neuropathic pain in Qatar.Qatar medical journal · 2021Article
- Review
- Postoperative Pain Management in Pediatric Spinal Fusion Surgery for Idiopathic Scoliosis.Paediatric drugs · 2020Review
- Paediatric adenotonsillectomy, part 2: considerations for anaesthesia.BJA education · 2020Review
- Knowledge and attitudes on pharmacogenetics among pediatricians.Journal of human genetics · 2020Article
- Comparisons of In Vivo and In Vitro Opioid Effects of Newly Synthesized 14-Methoxycodeine-6-Molecules (Basel, Switzerland) · 2020Article
- Post-Cardiotomy Parasternal Nerve Block with Bupivacaine may be Associated with Reduced Post-Operative Opioid Use in Children: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewUse of perioperative opioids for surgical pain management of children presents clinical challenges because of concerns of serious adverse effects including life-threatening respiratory depression. This is especially true for children with history of obstructive sleep apnea. This review will explore current knowledge of clinically relevant factors and genetic polymorphisms that affect opioid metabolism and postoperative outcomes in children. RECENT
findingsWithin the past several years, an increasing number of case reports have illustrated clinically important respiratory depression, anoxic brain injuries and even death among children receiving appropriate weight-based dosages of codeine and other opioids for analgesia at home setting particularly following tonsillectomy. Several national and international organizations have issued advisories on use of codeine in pediatrics, based on cytochrome P450 family 2 subfamily D type 6 (CYP2D6) pharmacogenetics. We have discussed the pros and cons of alternatives to codeine for pain management. SUMMARY: Although routine preoperative genotyping to identify children at risk and personalized opioid use for pediatric perioperative pain management is still a distant reality, current known implications of CYP2D6 pharmacogenetics on codeine use shows that pharmacogenetics has the potential to guide anesthesia providers on perioperative opioid selection and dosing to maximize efficacy and safety.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.