Evidence map›Paper›PMID 28323638›Full record

ArticlePhysics in medicine and biology2017

Fast lesion mapping during HIFU treatment using harmonic motion imaging guided focused ultrasound (HMIgFUS) in vitro and in vivo.

Yang Han, Shutao Wang, Thomas Payen, Elisa Konofagou

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05219695 (Medical Imaging and Focused Ultrasound Treatment for Breast Tumors Using Harmonic Motion Imaging), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05219695 phase1recruitingnot on this mapstarted 2022, after this paper: background citation

Medical Imaging and Focused Ultrasound Treatment for Breast Tumors Using Harmonic Motion Imaging (HMI)

TypeinterventionalSponsorColumbia UniversityRan2022 to 2031Enrolled82ConditionsFibroadenoma, Breast Cancer Stage IArmsHarmonic motion imaging guided focused ultrasound (HMIgFUS), Microbubble-mediated Low Intensity Focused Ultrasound (LIFU), Microbubbles
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Optimization of the Tracking Beam Sequence in Harmonic Motion Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024
    Article
  5. Article
  6. Therapeutic ultrasound transducer technology and monitoring techniques: a review with clinical examples.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Focused Ultrasound Steering for Harmonic Motion Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2018
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yang HanDepartment of Biomedical Engineering, Columbia University, New York, NY, United States of America.
Shutao WangDepartment of Biomedical Engineering, Columbia University, New York, NY, United States of America.
Thomas PayenDepartment of Biomedical Engineering, Columbia University, New York, NY, United States of America.
Elisa KonofagouDepartment of Biomedical Engineering, Columbia University, New York, NY, United States of America.
Columbia University · US

Funding

Ultrasound-based tumor targeting and thermal ablation monitoring systemR01EB014496 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2011 to 2014
$1.4M
NIBIB NIH HHS R01 EB014496
6 · The paper itself

Abstract

The successful clinical application of high intensity focused ultrasound (HIFU) ablation depends on reliable monitoring of the lesion formation. Harmonic motion imaging guided focused ultrasound (HMIgFUS) is an ultrasound-based elasticity imaging technique, which monitors HIFU ablation based on the stiffness change of the tissue instead of the echo intensity change in conventional B-mode monitoring, rendering it potentially more sensitive to lesion development. Our group has shown that predicting the lesion location based on the radiation force-excited region is feasible during HMIgFUS. In this study, the feasibility of a fast lesion mapping method is explored to directly monitor the lesion map during HIFU. The harmonic motion imaging (HMI) lesion map was generated by subtracting the reference HMI image from the present HMI peak-to-peak displacement map, as streamed on the computer display. The dimensions of the HMIgFUS lesions were compared against gross pathology. Excellent agreement was found between the lesion depth (r

Indexed as

AnimalsElasticity Imaging TechniquesHigh-Intensity Focused Ultrasound AblationMicePancreatic NeoplasmsRadiotherapy, Image-Guided

Identifiers

PMID28323638
PMCPMC5484394
OpenAlexW2600031787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.