Evidence map›Paper›PMID 28323322›Full record

ArticleClinical cardiology2017

Adaptations following an intermittent hypoxia-hyperoxia training in coronary artery disease patients: a controlled study.

Oleg Glazachev, Phylipp Kopylov, Davide Susta, Elena Dudnik, Elena Zagaynaya

Registry-linked trialOpen access · bronzeAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06451601 (The Metabolic and Respiratory Effects of Intermittent Hypoxia-hyperoxia Therapy in Obese Patients Within the Complex Management of Medical Rehabilitation), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06451601 nacompletednot on this mapstarted 2024, after this paper: background citation

The Metabolic and Respiratory Effects of Intermittent Hypoxia-hyperoxia Therapy in Obese Patients Within the Complex Management of Medical Rehabilitation

TypeinterventionalSponsorBalnear and Rehabilitation Sanatorium TechirghiolRan2024 to 2024Enrolled70ConditionsObesityArmsIntermittent hypoxia-hyperoxia therapy
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Oleg GlazachevI. M. Sechenov First Moscow State Medical University, Moscow, Russia.
Phylipp KopylovI. M. Sechenov First Moscow State Medical University, Moscow, Russia.
Davide SustaSchool of Health and Human Performance, Dublin City University, Dublin, Ireland.
Elena DudnikI. M. Sechenov First Moscow State Medical University, Moscow, Russia.
Elena ZagaynayaI. M. Sechenov First Moscow State Medical University, Moscow, Russia.
Sechenov University · RUDublin City University · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRepeated exposure to intermittent normobaric hypoxia improves exercise tolerance in cardiac patients. Little is known on the effects of intermittent normobaric hypoxia-hyperoxia exposure in coronary artery disease (CAD) patients (New York Heart Association II-III). HYPOTHESIS: IHHT improves exercise tolerance, cardiometabolic profile, and quality of life in CAD patients.

methodsThe study design was a nonrandomized, controlled, before-and-after trial. Forty-six CAD patients volunteered to take part in the study: a group of 27 patients undertook the intermittent hypoxia (O

resultsThe IHHG showed improved exercise capacity, reduced systolic and diastolic blood pressures, enhanced left ventricle ejection fraction, and reduced glycemia, but only at 1-month follow-up. Angina as a reason to stop exercising was significantly reduced after treatment and at 1-month follow-up. The IHHT SAQ profile was improved in the IHHG and not significantly different to the CTRL group after standard rehabilitation. The IHHG was also compared to the CTRL group at 1-month follow-up, and no differences were found.

conclusionsIn CAD patients, an IHHT program is associated with improved exercise tolerance, healthier risks factors profile, and a better quality of life. Our study also suggests that IHHT is as effective as an 8-week standard rehabilitation program.

Indexed as

HyperoxiaHypoxiaAdaptation, PhysiologicalAdultAgedAged, 80 and overBlood PressureCoronary Artery DiseaseExercise TestExercise TherapyExercise ToleranceFemaleHumansMaleMiddle AgedQuality of LifeIntermittent hypoxia-hyperoxia training, exercise tolerance, cardiometabolic profile, coronary artery disease, cardiac rehab

Identifiers

PMID28323322
PMCPMC6490434
OpenAlexW2600287003

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.