Evidence map›Paper›PMID 28323284›Full record

ArticleTranslational psychiatry2017

Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome.

D D Kiraly, S R Horn, N T Van Dam, S Costi, J Schwartz, S Kim-Schulze, M Patel, G E Hodes, S J Russo, M Merad and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 8 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 8 syntheses or guidelines pooled it, 177 citations in OpenAlex.

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  14. Acetyl-l-carnitine deficiency in patients with major depressive disorder.Proceedings of the National Academy of Sciences of the United States of America · 2018
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

D D KiralyMood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
S R HornMood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
N T Van DamMood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
S CostiMood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J SchwartzMood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
S Kim-SchulzeThe Immunology Institute, Human Immune Monitoring Core, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
M PatelThe Immunology Institute, Human Immune Monitoring Core, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
G E HodesFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
S J RussoFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
M MeradThe Immunology Institute, Human Immune Monitoring Core, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
D V IosifescuMood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
D S CharneyMood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J W MurroughMood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn School of Medicine at Mount Sinai · USAllen Institute for Brain Science · US

Funding

ROLE OF PERIPHERAL IMMUNE-DERIVED MMP8 IN STRESS SUSCEPTIBILITYR01MH104559 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT JAMES RUSSO · 2014 to 2026
$9.2M
NIMH NIH HHS R01 MH104559
6 · The paper itself

Abstract

A subset of patients with depression have elevated levels of inflammatory cytokines, and some studies demonstrate interaction between inflammatory factors and treatment outcome. However, most studies focus on only a narrow subset of factors in a patient sample. In the current study, we analyzed broad immune profiles in blood from patients with treatment-resistant depression (TRD) at baseline and following treatment with the glutamate modulator ketamine. Serum was analyzed from 26 healthy control and 33 actively depressed TRD patients free of antidepressant medication, and matched for age, sex and body mass index. All subjects provided baseline blood samples, and TRD subjects had additional blood draw at 4 and 24 h following intravenous infusion of ketamine (0.5 mg kg

Indexed as

AdultCase-Control StudiesChemokinesCytokinesDepressive Disorder, Treatment-ResistantExcitatory Amino Acid AntagonistsFemaleFibroblast Growth Factor 2HumansInflammationInfusions, IntravenousIntercellular Signaling Peptides and ProteinsInterleukin-1alphaInterleukin-1betaInterleukin-6KetamineChemokinesCytokinesExcitatory Amino Acid AntagonistsFibroblast Growth Factor 2IL1A protein, humanIL1B protein, humanIL6 protein, humanIntercellular Signaling Peptides and ProteinsInterleukin-1alphaInterleukin-1betaInterleukin-6KetamineTNF protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID28323284
PMCPMC5416674
OpenAlexW2601585445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.