ArticleThe ISME journal2017
Spontaneous mutations of a model heterotrophic marine bacterium.
Article in The ISME journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- A record-setting mitogenome in the holoparasitic plant Balanophora yakushimensis accompanied by exceptional loss of organellar DNA repair and recombination genes.BMC biology · 2025Article
- Genome reduction occurred in early Prochlorococcus with an unusually low effective population size.The ISME journal · 2024Article
- CDMAP/CDVIS: context-dependent mutation analysis package and visualization software.G3 (Bethesda, Md.) · 2023Article
- Prochlorococcus have low global mutation rate and small effective population size.Nature ecology & evolution · 2022Article
- Estimating the Divergence Times of Alphaproteobacteria Based on Mitochondrial Endosymbiosis and Eukaryotic Fossils.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Dating Alphaproteobacteria evolution with eukaryotic fossils.Nature communications · 2021Article
- Unexpectedly high mutation rate of a deep-sea hyperthermophilic anaerobic archaeon.The ISME journal · 2021Article
- Evolution of a Record-Setting AT-Rich Genome: Indel Mutation, Recombination, and Substitution Bias.Genome biology and evolution · 2020Article
- Investigating Evolutionary Rate Variation in Bacteria.Journal of molecular evolution · 2019Article
- Mode and Tempo of Microsatellite Length Change in a Malaria Parasite Mutation Accumulation Experiment.Genome biology and evolution · 2019Article
- First Estimation of the Spontaneous Mutation Rate in Diatoms.Genome biology and evolution · 2019Article
- Carbon limitation drives GC content evolution of a marine bacterium in an individual-based genome-scale model.The ISME journal · 2018Article
- Adaptation of Surface-Associated Bacteria to the Open Ocean: A Genomically Distinct Subpopulation ofFrontiers in microbiology · 2017Article
- Evolution of Dimethylsulfoniopropionate Metabolism in Marine Phytoplankton and Bacteria.Frontiers in microbiology · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Heterotrophic marine bacterioplankton populations display substantive genomic diversity that is commonly explained to be the result of selective forces imposed by resource limitation or interactions with phage and predators. Here we use a mutation-accumulation experiment followed by whole-genome sequencing of mutation lines to determine an unbiased rate and molecular spectrum of spontaneous mutations for a model heterotrophic marine bacterium in the globally important Roseobacter clade, Ruegeria pomeroyi DSS-3. We find evidence for mutational bias towards deletions over insertions, and this process alone could account for a sizable portion of genome size diversity among roseobacters and also implies that lateral gene transfer and/or selection must also play a role in maintaining roseobacters with large genome sizes. We also find evidence for a mutational bias in favor of changes from A/T to G/C nucleobases, which explains widespread occurrences of G/C-enriched Roseobacter genomes. Using the calculated mutation rate of 1.39 × 10
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