ArticleImmunology1988
Tumour necrosis factor beta (lymphotoxin) inhibits locomotion and stimulates the respiratory burst and degranulation of neutrophils.
Article in Immunology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- The Application of Dextran Sedimentation as an Initial Step in Neutrophil Purification Promotes Their Stimulation, due to the Presence of Monocytes.Journal of immunology research · 2017Article
- Hepatocyte growth factor stimulates neutrophil degranulation but not respiratory burst.Mediators of inflammation · 1993Article
- Effects of cytokines, complement, and antibody on the neutrophil respiratory burst and phagocytic response to Plasmodium falciparum merozoites.Infection and immunity · 1992Article
- CD4+ T cells are required for antigen-specific recruitment of neutrophils by BCG-immune spleen cells.Immunology · 1992Article
- Cytokine-induced (interleukins-3, -6 and -8 and tumour necrosis factor-beta) activation and deactivation of human neutrophils.Immunology · 1992Article
- A role for intestinal T lymphocytes in bronchus mucosal immunity.Immunology · 1991Article
- Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of gram-negative sepsis.The Journal of clinical investigation · 1991Article
- Decreased luminol-dependent chemiluminescence response of neutrophils to recombinant human tumour necrosis factor in patients with gastric cancer.Journal of cancer research and clinical oncology · 1991Article
- Production of tumor necrosis factors alpha and beta by human mononuclear leukocytes stimulated with mitogens, bacteria, and malarial parasites.Infection and immunity · 1990Article
- Article
- Neutrophil-mediated cartilage injury in vitro is enhanced by tumour necrosis factor alpha.Rheumatology international · 1990Article
- Staphylococcus aureus-stimulated mononuclear leucocyte-conditioned medium increases the neutrophil bactericidal activity, and augments oxygen radical production and degranulation in response to the bacteria.Clinical and experimental immunology · 1989Article
- T cell-dependent chronic neutrophilia during mycobacterial infections.Clinical and experimental immunology · 1989Article
- Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha.The Biochemical journal · 1989Article
- Augmentation of the neutrophil response to Naegleria fowleri by tumor necrosis factor alpha.Infection and immunity · 1989Article
- Tumor necrosis factor alpha potentiates neutrophil antimicrobial activity: increased fungicidal activity against Torulopsis glabrata and Candida albicans and associated increases in oxygen radical production and lysosomal enzyme release.Infection and immunity · 1989Article
- Production of lymphotoxin by isolated human tonsillar B lymphocytes and B lymphocyte cell lines.The Journal of clinical investigation · 1989Article
- Chemotactic activity of lymphotoxin and tumour necrosis factor alpha for human neutrophils.Immunology · 1989Article
- Tumour necrosis factors modulate the affinity state of the leukotriene B4 receptor on human neutrophils.Immunology · 1988Article
- Depression of immunity to Naegleria fowleri in mice by selective depletion of neutrophils with a monoclonal antibody.Infection and immunity · 1988Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The data presented here demonstrate that recombinant human tumour necrosis factor beta (rHuTNF beta; lymphotoxin) is a neutrophil modulator. The lymphokine inhibited the locomotion of neutrophils and augmented the neutrophil oxygen-dependent respiratory burst in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) and phorbol myristate acetate (PMA), as measured by their capacity to produce chemiluminescence, H2O2 and superoxide. The effects on the respiratory burst occurred at a tenth of the concentration of TNF beta required to inhibit locomotion. After incubation with TNF beta, the neutrophils could be washed without any reduction in their capacity to show augmented responses. The TNF beta enhanced granule enzyme (lysozyme and beta-glucuronidase) release of neutrophils stimulated with cytochalasin B-FMLP.
Indexed as
Identifiers
2832316PMC1454754W2401052060What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.