Evidence map›Paper›PMID 28322582›Full record

ArticleAIDS research and human retroviruses2017

Short Communication: Manα1-2Man-Binding Anti-HIV Lectins Enhance the Exposure of V2i and V3 Crown Neutralization Epitopes on the V1/V2 and V3 Hypervariable Loops of HIV-1 Envelope.

Muzafar Jan, Chitra Upadhyay, Aman Sharma, Catarina E Hioe, Sunil K Arora

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Muzafar Jan1 Department of Immunopathology, Post Graduate Institute of Medical Education and Research , Chandigarh, India .
Chitra Upadhyay2 Department of Infectious Diseases, Icahn School of Medicine , Mount Sinai, New York.
Aman Sharma3 Department of Internal Medicine, Post Graduate Institute of Medical Education and Research , Chandigarh, India .
Catarina E Hioe2 Department of Infectious Diseases, Icahn School of Medicine , Mount Sinai, New York.
Sunil K Arora1 Department of Immunopathology, Post Graduate Institute of Medical Education and Research , Chandigarh, India .
Post Graduate Institute of Medical Education and Research · IN

Funding

BLRD VA I01 BX003860BLRD VA IK6 BX004607
6 · The paper itself

Abstract

This study aimed to explore the contribution of high-mannose glycans in the masking of conserved V3 crown (GPG) and V2i epitopes on the hypervariable loops of most exposed distal surface of HIV-1 Env. Using lectins specific to Manα1-2Man residue containing Man

Indexed as

DisaccharidesEpitopesHIV-1HIV AntibodiesHIV Envelope Protein gp120HIV InfectionsHumansLectinsMannoseMannosidesNeutralization TestsPolysaccharidesDisaccharidesEpitopesHIV AntibodiesHIV Envelope Protein gp120LectinsMannoseMannosidesmannosyl alpha(1-6)-mannosidePolysaccharidesanti-HIV lectinsenvelopeHIV-1hypervariable loop epitopesN-linked glycans

Identifiers

PMID28322582
PMCPMC5576264
OpenAlexW2601573193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.